Busy. Please wait.

Forgot Password?

Don't have an account?  Sign up 

show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.

By signing up, I agree to StudyStack's Terms of Service and Privacy Policy.

Already a StudyStack user? Log In

Reset Password
Enter the email address associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know (0)
Know (0)
remaining cards (0)
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards

Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Surg 2 TP

Surgery 2

Describe the interaction btw cells with MHC and T-cell receptors Interact with T cells and stimulate them to either coordinate immune response (CD4 T cell) or directly attack microbes/ infected cell/ tumor cell (CD8 T cell)
MHC Class I: on surface of all nucleated cells (interact with CD8)
MHC Class II: on surface of APCs (interact with CD4)
Direct Pathway T-cells and their receptors identify foreign MHC molecules on donor cells. This stimulates CD8 T Cells to attack an organ and cause rejection
Indirect Pathway CD4 T cells recognize foreign proteins after presentation by APC’s (APC’s pick up peptides shed from transplanted organs)
Key component on T cell: TCR = Cell surface protein
Cytokine responsible for the majority of immune cell activation IL-2
Differences in survival between the various solid organs Kidney: 85%; Kidney/Pancreas: 85%; Liver: 74%; Heart: 72%; Lung: 47%; Intestine: 47%
Panel Reactive Antibodies (PRA): Recipient’s blood is tested for Abs that react vs panel of foreign cells; higher % indicates presence of more Abs, greater chance for rejection
Tolerance: state of immune acceptance without immunosuppression; the overall goal of TP (rarely achieved)
Hyperacute rejection immediate destruction (as soon as blood flows through vessels) of a transplanted organ
Acute Rejection Rejection of transplanted organ that most often occurs between 5-90 days after receiving a TP (caused by T-cells).
Chronic Rejection graft vasculopathy
Induction Immunosuppression Antilymphocyte Abs used to prevent rejection until maintenance suppression is therapeutic
Induction Immunosuppression: given when: Given before or at time of TP
Mainstay of LT immunosuppression tx: steroid tx (prednisone)
OKT3 MOA Directed against CD3 antigen on T cells, TCR is removed from lymphocyte surface membrane, lymph cannot fn
Zenapax & Simulect MOA Antibodies directed against IL-2 receptor
Inhibit DNA synthesis in quickly dividing cells antimetabolites
Cyclosporine / Tacrolimus MOA Binds to calcineurin / impairs intracellular cascades which results in the decreased expression of IL-2 and the IL-2 receptor
Sirolimus MOA prevents T cells from entering the cell cycle
Renal TP: 3 things to be sewn in: renal a., renal v., ureter
Used to assess renal TP post-op US
Renal TP complications ATN; lymphoceles; renal a/v thrombosis; urine leak
Why prefer the left kidney? left renal vein is longer
TP: CI include: lack of psychosocial support
Liver TP: candidate only if demonstrate: low risk for EtOH relapse
Liver TP: 5-yr survival: 85%
Liver TP: complications Primary non-function of graft; vanishing bile duct syndrome; Biliary Leak; Thrombosis of hepatic artery
Primary indication for panc TP T1DM (not T2DM)
Genl indication for TP end stage dz of the organ being transplanted
Heart TP: survival (1 & 5 yrs) 1 year survival is 80%, 5 year survival is 70%
Heart TP complications: right heart dysfunction, brady arrhythmias
Heart TP: Tachycardia is associated with: acute rejection
Lung TP: indicated for lung dz w/ life expectancy of: < 2 years
Lung TP survival (1 & 5 yr) 1 yr survival is 70%, 5 yr survival is 50%
Lung TP complications infxn (pneumonia); chronic rejection
Created by: Adam Barnard Adam Barnard