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Cardio 3
Generic | Brand | Pharmacologic Category | Common Indications | Essential Knowledge |
---|---|---|---|---|
dabigatran (PO) | Pradaxa | Anticoagulant, direct thrombin inhibitor | AF (stroke prevention), VTE | Key side effects: bleeding, dyspepsia US boxed warnings: premature discontinuation increases risk of thrombotic events Other notes: swallow whole, dispense and store in original packaging; discard 4 months after opening |
apixaban (PO) | Eliquis | Anticoagulant, factor Xa inhibitor | AF (stroke prevention), VTE | Key side effects: bleeding US boxed warnings: premature discontinuation increases risk of thrombotic events |
rivaroxaban (PO) | Xarelto | Anticoagulant, factor Xa inhibitor | AF (stroke prevention), VTE | Key side effects: bleeding US boxed warnings: premature discontinuation increases risk of thrombotic events |
warfarin (PO) | Coumadin, Jantoven | Anticoagulant, vitamin K antagonist | AF (stroke prevention), VTE | Key Side Effects: bleeding US Boxed Warnings: bleeding risk Other Notes: narrow therapeutic index drug (toxicity may occur at concentrations close to therapeutic range; therapeutic monitoring recommended with INR) Other Notes: dose dependent tablet colors; uniform vitamin K intake recommended; many drug interactions |
enoxaparin (SQ) | Lovenox | Anticoagulant, low molecular weight heparin | ACS, VTE | Key side effects: bleeding, hyperkalemia, HIT US Boxed warnings: increased risk of epidural or spinal hematoma in patient undergoing spinal puncture Other notes: do not expel air bubble from syringe prior to injection |
heparin (IV, SQ) | - - - - | Anticoagulant | ACS, VTE | Key side effects: bleeding, hyperkalemia, HIT |
clopidogrel (PO) | Plavix | Antiplatelet agent | CAD, stroke | Key side effects: bleeding US Boxed Warnings: diminished effectiveness in poor metabolizers |
dipyridamole and aspirin (PO) | Aggrenox | Antiplatelet agent | Stroke | Key side effects: bleeding, headache |
prasugrel (PO) | Effient | Antiplatelet agent | CAD | Key side effects: bleeding US Boxed Warnings: bleeding risk Other notes: CI in patients with history of stroke |
alteplase (intracatheter, IV) | Intracatheter: Cathflo, IV: Activase | Fibrinolytic | IC: catheter clearance IV: STEMI, ischemic stroke, PE | Key side effects: bleeding Other notes: CI in patients with severe uncontrolled HTN |