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Immune Complex III
Immunology and Serology
Question | Answer |
---|---|
How is the formation of immune complexes protective? | The formation of immune complexes is protective because complexes facilitate clearance of antigens and invading microorganisms by phagocytic system |
What happens in immune complex reactions? | Ag/Ab complexes form in fluid phase of tissues or blood and assume unique biologic functions such as interactions with complement or cellular receptors |
What are some examples of immune complex (Type III) reactions? | Arthus reactionSerum sicknessSome autoimmune disease such as glomerulonephritis in SLE |
What happens when Ab reacts with soluble Ag in circulation? | The formation of complexes that may disseminate and lodge in any tissue with large filtration area and cause lesion of immune complex disease. |
What happens when there is a formation of complexes that may disseminate and lodge in any tissue with large filtration area and cause lesion of immune complex disease? | experimental Arthus reaction, farmer’s lung disease |
What happens when Ab reacts with structural Ags that form part of cell surface membranes or with fixed intercellular structures such as basement membranes? | serum sickness = develops within 1 to 2 weeks after initial exposure or repeated exposure by injection of heterologous serum protein |