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Cardio 3
BDK
generic | brand | pharmacologic category | common indication | essential knowledge |
---|---|---|---|---|
Dabigatran (PO) | Pradaxa | anticoagulant, direct thrombin inhibitor | AF (stroke prevention), VTE | Key Side Effects: bleeding, dyspepsia US Boxed Warnings: premature discontinuation increases risk of thrombotic events Other Notes: swallow whole; dispense and store in original packaging; discard 4 months after opening |
Apixaban (PO) | Eliquis | anticoagulant, factor Xa inhibitor | AF (stroke prevention), VTE | Key Side Effects: bleeding US Boxed Warnings: premature discontinuation increases risk of thrombotic events |
Rivaroxaban (PO) | Xarelto | anticoagulant, factor Xa inhibitor | AF (stroke prevention), VTE | Key Side Effects: bleeding US Boxed Warnings: premature discontinuation increases risk of thrombotic events |
Warfarin (PO) | Coumadin, Jantoven | anticoagulant, Vitamin K antagonist | AF (stroke prevention), VTE | Key Side Effects: bleeding US Boxed Warnings: bleeding risk Other Notes: narrow therapeutic index drug (toxicity may occur at concentrations close to therapeutic range; therapeutic monitoring recommended with INR) Other Notes: dose dependent tablet col |
Enoxaparin (SQ) | Lovenox | anticoagulant, low molecular weight heparin | ACS, VTE | Key Side Effects: bleeding, hyperkalemia, HIT US Boxed Warnings: increased risk of epidural or spinal hematoma in patient undergoing spinal puncture Other Notes: do not expel air bubble from syringe prior to injection |
Heparin (IV, SQ) | ---- | anticoagulant | ACS, VTE | Key Side Effects: bleeding, hyperkalemia, HIT |
Clopidogrel (PO) | Plavix | anti-platelet agent | CAD, stroke | Key Side Effects: bleeding US Boxed Warnings: diminished effectiveness in poor metabolizers |
Dipyridamole and aspirin (PO) | Aggrenox | Antiplatelet agent | Stroke | Key Side Effects: bleeding, headache |
Prasugrel (PO) | Effient | antiplatelet agent | CAD | Key Side Effects: bleeding US Boxed Warnings: bleeding risk Other Notes: CI in patients with history of stroke |
Alteplase (intracatheter, IV ) | Intracatheter : Cathflo IV: Activase | Fibrinolytic | Intracatheter : catheter clearance, IV: STEMI, ischemic stroke, PE | Key Side Effects: bleeding Other Notes: CI in patients with severe uncontrolled HTN AF: |