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IMC512 Renal

Flashcards 4: Extracellular Fluid Volume Balance

QuestionAnswerAdditional Information
What are the two main stimuli for ADH release? Low ECFV, high osmolality
What is the main action of ADH on the collecting duct? Increases AQP2 abundance, raising tubular water permeability, and water reabsorption.
The natriuretic peptides ANP and BNP are released from ____ in response to ____ cardiac myocytes, stretch A rise in ECFV stretches the myocytes. The natruiretic peptides encourage fluid loss to lower ECFV.
What are the three triggers for aldosterone release? [1] A rise in AngII, [2] Sympathetic innervation of the adrenal cortex (due to low ECFV), [3] Hyperkalemia
What is the main effect of aldosterone on the kidney? Increases salt reabsorption by the distal tubule and collecting duct Acts by upregulating ENaC, ROMK, and the Na/K-ATPase.
What is the effect of the natriuretic peptides on GFR? Raises GFR to encourage fluid loss Dilates the afferent and constricts the efferent.
What is the mechanism of action of the diuretic spironolactone? Antagonizes the mineralocorticoid receptor, blocking aldosterone action. The result is salt wasting and diuresis
A pressure drop in the afferent arteriole causes the release of which protein? renin renin is an enzyme that is important for creating the vasocontrictor AngII
Created by: IMC512
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