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IMC512 Renal

Flashcards 2: Glomerular Filtration

QuestionAnswerAdditional Information
What is the equation for filtration fraction? GFR/RPF In health GFR~ 600 mL/min, RPF ~120 mL/min, so FF ~ 0.2.
The ultrafiltration barrier is selective based on which two criteria? Particle size and charge Discourages filtration of large and negatively charged substances.
An increase in which glomerular capillary Starling force would cause a drop in GFR? Oncotic ('Pi'GC) GFR is proportional to PGC-PBS-'Pi'GC
GFR is the ratio of urine/plasma [inulin] multiplied by what other term? urine flow rate GFR = (UxV)/P
The clearance of which substance is a proxy for renal plasma flow? paraaminohippurate (PAH) PAH clearance slightly underestimates RPF because it is not 100% secreted from plasma
The clearance of which substance is a proxy for GFR? inulin or creatinine creatinine clearance slightly overestimates GFR because it is secreted by the proximal tubule
If the clearance of a substance 'X' is lower than GFR, is that substance secreted or reabsorbed by the nephron? reabsorbed Clearance of a substance that is neither reabsorbed or secreted by the nephron = GFR.
GFR is an important clinical metric because it reports kidney function GFR is proportional to the number of functioning nephrons
Created by: IMC512
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