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CEN Med Toxicity

Medicine toxicity symptoms and curative measures

Medicine Symptoms and antidote
Acetaminophen toxicity Antidote: N-acetylcysteine (mucomyst)
Acetaminophen symptoms Liver failure symptoms - Take blood test 4 HOURS after ingestion
Aspirin toxicity Antidote: Bicarb (remember aspirin is salacytic ACID so need bicarb to counteract) - More common in elderly - Tinnitus
Benzodiazepine toxicity Antidote: flumazenil/Romanzicon – (don’t give to chronic users/alcoholics because the immediate withdrawal can give them seizures) - Manage Airway and Hypotension
Sulfonylurea toxicity (meds that lower blood glucose) Antidote - Octreotide (and treat hypoglycemia)
Phenothiazine (1st gen antipsychotics) toxicity Give Benadryl
Calcium channel blocker toxicity antidote Give large doses of calcium (and treat hyperglycemia)
Calcium channel blocker symptoms Monitor for Dysrhythmias, HYPOtension, HYPERglycemia
Beta blocker toxicity Give glucagon (and treat HYPOglycemia)
Digitalis Toxicity Give digoxin - Monitor potassium
Digoxin toxicity - May be seeing yellow halos – - Give digibind
Iron toxicity Give DesFEral – may turn urine orange/pink - Charcoal is CONTRAINDICATED - More common OD in peds bc vitamins taste like candy - Gi symptoms - GI bleed/hemorrhage (prepare for transfusion)
Tricyclic Antidepressants Toxicity antidote Give bicarb
Tricyclic Antidepressants Toxicity symptoms These meds are anticholinergics and alpha blocker so tachycardia and hypotension possible Rapid decline in condition - 3 C’s of overdose: Cardiac dysrhythmias, Convulsions (seizures), Coma
Heparin toxicity antidote Protamine sulfate
Ibuprofen toxicity management Supportive care, symptom management
Ibuprofen toxicity symptom symptoms GI symptoms - GI hemorrhage CNS depression Renal toxicity
Created by: HKRN
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