Cytotoxic T-cells aka:

KILLER T-CELLS (NOT same as NK cells)

CYTOTOXICCells - can directly attack cells infected w: 5+

viruses, parasites, cancers, bacteria, transplants, etc...

CYTOTOXIC Cells include:

(CD8,T8,CTL,Tc) and (ANaB T-cell)

Sequence of attack of Cytotoxic T-cells is:

1)Bind to target & release PERFERIN, LYMPHOTOXIN or TUMOR NECROSIS FACTOR (TNF) 2)Detach & search for a new cell 3)Perforin,lymphotoxin or TNF will cause lysis

TNF causes lysis by an:

unknown mechanism that cell death within 48-72 hours

CD4, Regulatory (CD4,T4,Th) (ANaB T-cell)

Helper T-cells chemically or directly stimulate:

proliferation of other T-cells & B-cells that are already bound to the antigen

Helper T-cells-stimulated to work:

by CYTOKINES called lymphokines

LYMPHOKINES are hormone like:

soluble glycoproteins released by activated T-cells, specifically INTERLEULIN-2

Lymphokines released by helper T-cells mobilize:

immune cells & macrophages, attract other types of WBC's & amplify nonspecific defenses

Th's are said to unleash the:

protective potential of B-cells

Some T-cells, require two:

controlling steps to become completely activated

Helper T-cells assist both T-cells & B-cells by providing:

regulation for thier activation

antigen is presented & attached to a T-cell or B-cell membrane

CO-STIMULATION: The CD28 receptor on a:

cytotoxic T-cell attaches to a B7 receptor on a macrophage or receives chemical activation foam a diff T-cell or a B-cell

Once stimulated (during co-stimulation) it can:

proliferate and produce many cytotoxic T-cella as well as T-memory cells

ANERGY refers to the fact that:

if a T or B cell does not get proper co-stimulation it will not activate

SUPPRESSOR T-Cells are:

regulatory (CD8,Ts) (ANaBT-cell)

Which T-cell has inhibitory action and what do they do:

supressor; they release luymphokines that suppress both B & T cells.

Suppressor (regulatory) T Cells are:

vital for shutting down immune response when emergency ends

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Stack #36925

A&P2-ClassNotes p 41 Immune Sys #10/Test3

Question	Answer
Cytotoxic T-cells aka:	KILLER T-CELLS (NOT same as NK cells)
CYTOTOXICCells - can directly attack cells infected w: 5+	viruses, parasites, cancers, bacteria, transplants, etc...
Primary target-CYTOTOXIC cells:	virus-infected cells
Cytotoxic T-cells circulate:	in/out of blood vessels
CYTOTOXIC Cells include:	(CD8,T8,CTL,Tc) and (ANaB T-cell)
Sequence of attack of Cytotoxic T-cells is:	1)Bind to target & release PERFERIN, LYMPHOTOXIN or TUMOR NECROSIS FACTOR (TNF) 2)Detach & search for a new cell 3)Perforin,lymphotoxin or TNF will cause lysis
Perforin provokes cell lysis by:	creating transmembrane pores
Lymphotoxin causes lysis by:	fragmenting target cells DNA
TNF causes lysis by an:	unknown mechanism that cell death within 48-72 hours
CYTOTOXIC t-Cells are CD:	CD8
HELPER T-CELLS:	CD4, Regulatory (CD4,T4,Th) (ANaB T-cell)
Helper T-cells chemically or directly stimulate:	proliferation of other T-cells & B-cells that are already bound to the antigen
Helper T-cells-stimulated to work:	by CYTOKINES called lymphokines
LYMPHOKINES are hormone like:	soluble glycoproteins released by activated T-cells, specifically INTERLEULIN-2
Lymphokines released by helper T-cells mobilize:	immune cells & macrophages, attract other types of WBC's & amplify nonspecific defenses
Some ThCD4's become:	T-cell memory (Tm) cells
Th's are said to unleash the:	protective potential of B-cells
B-cells are activated as soon as:	they encounter an antigen
Some T-cells, require two:	controlling steps to become completely activated
Helper T-cells assist both T-cells & B-cells by providing:	regulation for thier activation
There are 2 steps to activation:	ADHESION & C0-STIMULATION
ADHESION: an	antigen is presented & attached to a T-cell or B-cell membrane
CO-STIMULATION: The CD28 receptor on a:	cytotoxic T-cell attaches to a B7 receptor on a macrophage or receives chemical activation foam a diff T-cell or a B-cell
Once stimulated (during co-stimulation) it can:	proliferate and produce many cytotoxic T-cella as well as T-memory cells
ANERGY refers to the fact that:	if a T or B cell does not get proper co-stimulation it will not activate
SUPPRESSOR T-Cells are:	regulatory (CD8,Ts) (ANaBT-cell)
Which T-cell has inhibitory action and what do they do:	supressor; they release luymphokines that suppress both B & T cells.
Suppressor (regulatory) T Cells are:	vital for shutting down immune response when emergency ends
CYTOTOXIC T-cells AKA:	Effectors

Created by: Jean and Study Pals

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