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MIGRAINES
Zolmitriptan
Question | Answer |
---|---|
Expected pharmacological action | Activation of 5HT Receptors which causes vasoconstriction and reduction in neurotransmission. |
Theraputic Use | Acute migraine headache pain - Selective serotonin drugs are used for the relief of moderate to severe pain and inflammation related to migraine headaches |
ADRs | ****FLUSHING**** Headache Nausea Dizziness Chest pain Paresthesia into neck dry mouth |
Contraindications | Allergy to Selective serotonin agonists Ischemic heart disease (cardiovascular), transient ischemic attacks, uncontrolled hypertension, clients taking monoamine oxidase inhibitors (5-HT agonists)(antidepressant) |
Precautions | Hepatic and Renal Impairment Elderly Dialysis Pregnancy category C Lactation |
Interactions | Cimetidine - Increased effectiveness of 5-HT agonist Oral Contraceptives - Increased effectiveness of 5-HT agonist |
Watch out for... | Serotonin syndrome |
MAX Dose | 10mg in a 24 hr period |
Client Education | Subcutaneous Injection Administration - only 2 injections in a 24 hour period Impaired skin integrity - become sensitive to light - wear protective clothing and sunscreen when outside - UV rays dangerous, no tanning beds |