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VMD 461C Sykes

Infectious Disease

QuestionAnswer
What does a rabid animal look like? -3 phases: prodromal, furious, paralytic -anxiety,docile -excitability, barking,biting, pica, pharyngeal/laryngeal spasm, muscle tremor, seizure, coma, death - change in voice, "choking", dropped jaw - respiratory muscle paralysis, coma/death in 2-4
How is rabies transmitted? -nearly always by biting -rarley by aerosol in caves -ingestion of infected tissue -mucosal contact with saliva -transplants
What should you do if rabies is on your list of differentials? -Animals with suspected rabies should be handled with extreme caution and euthanized as soon as possible. Treatment should not be attempted.
How is rabies infection confirmed? **direct FA for virus (brain) -RT-PCR/culture of saliva
What do you tell a client who calls worried about rabies because his dog was bitten by a squirrel? Rodent species are rarely infected with rabies. Check vaccine status.
What do you tell a client who calls worried about rabies because his dog was bitten by a racoon? Depends on vaccine status. Unvaccinated: euthanize or quarantine for 6mo then vaccinate 1mo before release. Vaccinated: revaccinate then confine for 45d
If you are bitten by a rabid animal, will you definitely contract disease?
How long after exposure to rabies will it take before you develop clinical signs? humans - 3wks to >1yr Dogs and cats - 1 to 2mo
Is there any way of preventing disease after exposure to rabies? -inj of human rabies Ig + vax x5 over 1mo -if vaccinated, no HR-IG, and only 2 vax doses
When should you vaccinate for rabies? -4mo -1yr later -q 1-3yrs depending on vax and local regulations
How good are the vaccines for rabies? Are there any adverse effects? good; vaccination is the single best measure for prevention adverse effects include postvaccinal rabies (MLV), vaccine rxn, vaccine-induced sarcoma
If one of your patients bites someone, what are the rules for rabies prevention and why? healthy vaccinated: confine/observe 10d unvaccinated: euthanize and test, or Q. 10d in hospital stray: euthanize and test
what's the most important reservoir of rabies in the US? -the skunk -tons of virus in the saliva -can be chronically infected -can adapt to human environments
Pathogenesis of rabies virus infection -bite wound -virus multiplies in myocytes (wks to months) -virus travels up peripheral nerves to CNS and multiplies -encephalitis -virus moves out through peripheral/cranial nerves -saliva infective for days before clinical signs
Created by: modonnell
 

 



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