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VMD 461C Sykes
Infectious Disease
| Question | Answer |
|---|---|
| What does a rabid animal look like? | -3 phases: prodromal, furious, paralytic -anxiety,docile -excitability, barking,biting, pica, pharyngeal/laryngeal spasm, muscle tremor, seizure, coma, death - change in voice, "choking", dropped jaw - respiratory muscle paralysis, coma/death in 2-4 |
| How is rabies transmitted? | -nearly always by biting -rarley by aerosol in caves -ingestion of infected tissue -mucosal contact with saliva -transplants |
| What should you do if rabies is on your list of differentials? | -Animals with suspected rabies should be handled with extreme caution and euthanized as soon as possible. Treatment should not be attempted. |
| How is rabies infection confirmed? | **direct FA for virus (brain) -RT-PCR/culture of saliva |
| What do you tell a client who calls worried about rabies because his dog was bitten by a squirrel? | Rodent species are rarely infected with rabies. Check vaccine status. |
| What do you tell a client who calls worried about rabies because his dog was bitten by a racoon? | Depends on vaccine status. Unvaccinated: euthanize or quarantine for 6mo then vaccinate 1mo before release. Vaccinated: revaccinate then confine for 45d |
| If you are bitten by a rabid animal, will you definitely contract disease? | |
| How long after exposure to rabies will it take before you develop clinical signs? | humans - 3wks to >1yr Dogs and cats - 1 to 2mo |
| Is there any way of preventing disease after exposure to rabies? | -inj of human rabies Ig + vax x5 over 1mo -if vaccinated, no HR-IG, and only 2 vax doses |
| When should you vaccinate for rabies? | -4mo -1yr later -q 1-3yrs depending on vax and local regulations |
| How good are the vaccines for rabies? Are there any adverse effects? | good; vaccination is the single best measure for prevention adverse effects include postvaccinal rabies (MLV), vaccine rxn, vaccine-induced sarcoma |
| If one of your patients bites someone, what are the rules for rabies prevention and why? | healthy vaccinated: confine/observe 10d unvaccinated: euthanize and test, or Q. 10d in hospital stray: euthanize and test |
| what's the most important reservoir of rabies in the US? | -the skunk -tons of virus in the saliva -can be chronically infected -can adapt to human environments |
| Pathogenesis of rabies virus infection | -bite wound -virus multiplies in myocytes (wks to months) -virus travels up peripheral nerves to CNS and multiplies -encephalitis -virus moves out through peripheral/cranial nerves -saliva infective for days before clinical signs |