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Pain, etc. 1

Pain, Hematology, and Oncology 1

Generic NameBrand NamePharmacologic CategoryCommon IndicationsKey Side Effects/Other NotesUS Boxed Warning US Boxed Warning Cont.US Boxed Warning Cont>Other Notes Cont.
fentanyl (transdermal, IV) Transdermal: Duragesic, IV: Sublimaze Opioid analgesic Pain Key Side Effects: dizziness, drowsiness, itching, nausea, vomiting, constipation, respiratory depression (dose-related) US Boxed Warning (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; US Boxed Warning Cont.: ....prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid- induced withdrawal syndrome; US Boxed Warning Cont.: .... concomitant use of opioids with benzodiazepines or CNS depressants (including alcohol), may result in profound sedation, respiratory depression, coma, and death
hydromorphone (PO, IV) Dilaudid Opioid analgesic Pain Key Side Effects: dizziness, drowsiness, itching, nausea, vomiting, constipation, respiratory depression (dose-related) US Boxed Warning (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; US Boxed Warning Cont.: ....prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid- induced withdrawal syndrome; US Boxed Warning Cont.: .... concomitant use of opioids with benzodiazepines or CNS depressants (including alcohol), may result in profound sedation, respiratory depression, coma, and death
morphine (extended release) (PO) MS Contin, Kadian Opioid analgesic Pain Key Side Effects: dizziness, drowsiness, itching, nausea, vomiting, constipation, respiratory depression (dose-related) US Boxed Warning (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; US Boxed Warning Cont.: ....prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid- induced withdrawal syndrome; US Boxed Warning Cont.: .... concomitant use of opioids with benzodiazepines or CNS depressants (including alcohol), may result in profound sedation, respiratory depression, coma, and death
morphine (immediate release) (PO, IV, IM, PR) IV: Duramorph Opioid analgesic Pain Key Side Effects: dizziness, drowsiness, itching, nausea, vomiting, constipation, respiratory depression (dose-related) US Boxed Warning (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; US Boxed Warning Cont.: ....prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid- induced withdrawal syndrome; US Boxed Warning Cont.: .... concomitant use of opioids with benzodiazepines or CNS depressants (including alcohol), may result in profound sedation, respiratory depression, coma, and death
oxycodone (PO) Oxycontin, Roxicodone Opioid analgesic Pain Key Side Effects: dizziness, drowsiness, itching, nausea, vomiting, constipation, respiratory depression (dose-related) US Boxed Warning (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; US Boxed Warning Cont.: ....prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid- induced withdrawal syndrome; US Boxed Warning Cont.: .... concomitant use of opioids with benzodiazepines or CNS depressants (including alcohol), may result in profound sedation, respiratory depression, coma, and death
methadone (PO, IV) Dolophine Opioid analgesic Opioid use disorder, severe chronic pain Key Side Effects: dizziness, drowsiness, itching, nausea, vomiting, constipation, respiratory depression (dose-related) US Boxed Warning: QTc interval prolongation and serious arrhythmia (Torsades de Pointes) have occurred during treatment
acetaminophen (PO, PR, IV) * PO/PR: Tylenol, IV: Ofirmev Analgesic (non-opioid), antipyretic Pain, fever Key Side Effects: nausea, vomiting, increased hepatic transaminases US Boxed Warning: total daily dose from all sources should not exceed maximum daily limit; hepatotoxicity
tramadol (PO) Ultram, Ultram ER Central analgesic; partial opioid agonist Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related) Other Notes: lowers seizure threshold US Boxed Warning: serious or fatal respiratory depression may occur
hydrocodone and acetaminophen (PO) Lortab, Vicodin, Norco Opioid and nonopioid analgesic combination Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related) US Boxed Warning (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; US Boxed Warning Cont.: ....prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid- induced withdrawal syndrome; US Boxed Warning Cont.: .... concomitant use of opioids with benzodiazepines or CNS depressants (including alcohol), may result in profound sedation, respiratory depression, coma, and death
oxycodone and acetaminophen (PO) Percocet, Endocet, Roxicet Opioid and nonopioid analgesic combination Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related) US Boxed Warning (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; US Boxed Warning Cont.: ....prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid- induced withdrawal syndrome; US Boxed Warning Cont.: .... concomitant use of opioids with benzodiazepines or CNS depressants (including alcohol), may result in profound sedation, respiratory depression, coma, and death
codeine and acetaminophen (PO) Tylenol with Codeine #3, Tylenol with Codeine #4 Opioid and nonopioid analgesic combination Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related) US Boxed Warning (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; US Boxed Warning Cont.: ....prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid- induced withdrawal syndrome; US Boxed Warning Cont.: .... concomitant use of opioids with benzodiazepines or CNS depressants (including alcohol), may result in profound sedation, respiratory depression, coma, and death
naloxone (IV, IM, SQ, intranasal) Narcan Opioid antagonist Opioid overdose Key Side Effects: headache, opioid withdrawal syndrome in opioid- dependent populations, pain, diaphoresis
buprenorphine and naloxone (SL) Suboxone Partial opioid agonist and opioid antagonist Opioid use disorder Key Side Effects: headache, opioid withdrawal syndrome in opioid- dependent populations, pain, diaphoresis Other Notes: potentially life-threatening respiratory depression (when combined with other CNS and respiratory depressants); Other Notes Cont.: ...addition of naloxone to buprenorphine reduces possibility of parenteral misuse by producing opioid withdrawal symptoms when injected
Created by: brookenicole1496
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