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Musculoskeletal

Generic NameBrand NamePharmacologic CategoryCommon Indications Key Side Effects/Other NotesUS Boxed Warning US Boxed Warning Cont. US Boxed Warning Cont.
tizanidine (PO) Zanaflex Alpha2 agonist Spasticity Key Side Effects: drowsiness, hypotension, dizziness, xerostomia, weakness
hydroxychloroquine (PO) Plaquenil Aminoquinolone RA, SLE, malaria Key Side Effects: retinal toxicity, rash, diarrhea Other Notes: use has been associated with cardiomyopathy, bone marrow suppression, and neuromuscular effects (i.e., myopathy, palsies, and progressive weakness)
colchicine (PO) Colcrys Antigout agent Gout Key Side Effects: diarrhea, nausea, vomiting, bone marrow suppression, myopathy (including rhabdomyolysis
diclofenac (PO) Voltaren NSAID OA, RA, acute pain Key Side Effects: diarrhea, dyspepsia, abdominal pain, flatulence, nausea Other Notes: may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis) US Boxed Warning: may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; US Boxed Warning: ....... may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation
ibuprofen (PO) * Motrin, Advil NSAID OA, RA, acute pain Key Side Effects: diarrhea, dyspepsia, abdominal pain, flatulence, nausea Other Notes: may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis) US Boxed Warning: may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; US Boxed Warning: ....... may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation
meloxicam (PO) Mobic NSAID OA, RA, acute pain Key Side Effects: diarrhea, dyspepsia, abdominal pain, flatulence, nausea Other Notes: may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis) US Boxed Warning: may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; US Boxed Warning: ....... may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation
indomethacin (PO) Indocin NSAID OA, RA, acute pain, gout Key Side Effects: diarrhea, dyspepsia, abdominal pain, flatulence, nausea Other Notes: may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis) US Boxed Warning: may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; US Boxed Warning: ....... may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation
naproxen (PO) * Naprosyn, Anaprox, Aleve NSAID OA, RA, acute pain, gout Key Side Effects: diarrhea, dyspepsia, abdominal pain, flatulence, nausea Other Notes: may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis) US Boxed Warning: may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; US Boxed Warning: ....... may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation
ketorolac (PO, IV) Toradol NSAID Pain Key Side Effects: diarrhea, dyspepsia, abdominal pain, flatulence, nausea Other Notes: may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis) US Boxed Warning: may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; US Boxed Warning: ....... may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation US Boxed Warning (only for ketorolac) indicated for short term use (≤ 5 days)
celecoxib (PO) Celebrex NSAID, COX-2 selective OA, RA, acute pain Key Side Effects: diarrhea, dyspepsia, abdominal pain, flatulence, nausea Other Notes: may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis) US Boxed Warning: may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; US Boxed Warning: ....... may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation
diclofenac (topical) * Voltaren Gel NSAID OA Key Side Effects: pruritus, rash
cyclobenzaprine (PO) Flexeril Skeletal muscle relaxant Muscle spasm Key Side Effects: drowsiness, dizziness, xerostomia, fatigue Other Notes: use may cause prolonged cardiac arrhythmias, and tachycardia; CI within 14 days of MAOI inhibitor therapy
baclofen (PO) ------- Skeletal muscle relaxant Spasticity Key Side Effects: drowsiness Other Notes: drug abuse potential (carisoprodol only)
carisoprodol (PO) Soma Skeletal muscle relaxant Muscle spasm Key Side Effects: drowsiness Other Notes: drug abuse potential (carisoprodol only)
methocarbamol (PO) Robaxin Skeletal muscle relaxant Muscle spasm Key Side Effects: drowsiness Other Notes: drug abuse potential (carisoprodol only)
metaxalone (PO) Skelaxin Skeletal muscle relaxant Muscle spasm Key Side Effects: drowsiness Other Notes: drug abuse potential (carisoprodol only)
lidocaine (transdermal *, IV) Transdermal: Lidoderm, IV: Xylocaine Transdermal: topical analgesic IV: antiarrhythmic Transdermal: pain, IV: ventricular arrhythmias Key Side Effects (transdermal): dermatitis, erythema, urticaria, skin depigmentation, skin edema Key Side Effects (IV) bradycardia Other Notes: patch may remain in place for up to 12 hours in any 24-hour period, patch may be cut
allopurinol (PO) Zyloprim Xanthine oxidase Inhibitor Gout Key Side Effects: diarrhea, nausea, rash, leukopenia, thrombocytopenia Other Notes: rare association with severe (and potentially fatal) allopurinol hypersensitivity syndrome (risk highest in certain Asian populations)
succinylcholine (IV) Anectine Depolarizing neuromuscular blocking agent Neuromuscular blockade for intubation or procedures Key Side Effects: hyperkalemia, myalgia, malignant hyperthermia (rare) US Boxed Warning: acute rhabdomyolysis and hyperkalemia leading to cardiac arrest and death in pediatric patients with undiagnosed skeletal muscle disease
Created by: brookenicole1496
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