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Cardio Disease 3
Cardiovascular Disease 3
Generic Name | Brand Name | Pharmacologic Category | Common Indications | Key Side Effects/Other Notes | US Boxed Warning |
---|---|---|---|---|---|
dabigatran (PO) | Pradaxa | Anticoagulant, direct thrombin inhibitor | AF (stroke prevention), VTE | Key Side Effects: bleeding, dyspepsia Other Notes: swallow whole; dispense and store in original packaging; discard 4 months after opening | US Boxed Warning: premature discontinuation increases risk of thrombotic events |
apixaban (PO) | Eliquis | Anticoagulant, factor Xa inhibitor | AF (stroke prevention), VTE | Key Side Effects: bleeding | US Boxed Warning: premature discontinuation increases risk of thrombotic events |
rivaroxaban (PO) | Xarelto | Anticoagulant, factor Xa inhibitor | AF (stroke prevention), VTE | Key Side Effects: bleeding | US Boxed Warning: premature discontinuation increases risk of thrombotic events |
warfarin (PO) | Coumadin, Jantoven | Anticoagulant, vitamin K antagonist | AF (stroke prevention), VTE | Key Side Effects: bleeding Other Notes: narrow therapeutic index drug (toxicity may occur at concentrations close to therapeutic range; therapeutic monitoring recommended with INR) | Other Notes Cont.: dose dependent tablet colors; uniform vitamin K intake recommended; many drug interactions |
enoxaparin (SQ) | Lovenox | Anticoagulant, low molecular weight heparin | ACS, VTE | Key Side Effects: bleeding, hyperkalemia, HIT Other Notes: do not expel air bubble from syringe prior to injection | US Boxed Warning: increased risk of epidural or spinal hematoma in patient undergoing spinal puncture |
heparin (IV, SQ) | ------- | Anticoagulant | ACS, VTE | Key Side Effects: bleeding, hyperkalemia, HIT | |
clopidogrel (PO) | Plavix | Antiplatelet agent | CAD, stroke | Key Side Effects: bleeding | US Boxed Warning: diminished effectiveness in poor metabolizers |
dipyridamole and aspirin (PO) | Aggrenox | Antiplatelet agent | Stroke | Key Side Effects: bleeding, headache | |
prasugrel (PO) | Effient | Antiplatelet agent | CAD | Key Side Effects: bleeding Other Notes: Cl in patients with history of stroke | US Boxed Warning: bleeding risk |
alteplase (intracatheter, IV) | Intracatheter: Cathflo, IV: Activase | Fibrinolytic | Intracatheter: catheter clearance IV: STEMI, ischemic stroke, PE | Key Side Effects: bleeding Other Notes: Cl in patients with severe uncontrolled HTN |