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Hematology OOF

QuestionAnswer
Which abnormal hemoglobin may be formed in alpha thalassemia? Hb Bart's
Hemoglobin Lepore abnormal hemoglobin due to the fusion of delta and beta chains resulting from a fusion gene formed by unequal crossing over.
Hemoglobin E hemoglobinopathy resulting from a single amino acid substitution on the beta chain. In hemoglobin E, lysine substitutes for glutamic acid on the 26th position of the beta chain.
Hemoglobin S hemoglobinopathy resulting from a single amino acid substitution on the beta chain. In hemoglobin S, valine substitutes for glutamic acid on the sixth position of the beta chain.
primary myelofibrosis - bone marrow is filled with fibrous tissue - extramedullary hematopoiesis - Teardrop RBCs - Nucleated RBCs - Immature myeloid cells in the peripheral blood
Polycythemia vera - general increase in red blood cells
infectious mononucleosis - an infection caused by the Epstein-Barr virus (EBV) - fever, a sore throat, and enlarged lymph nodes - Reactive lymphocytes
nonmegaloblastic anemia liver disease, alcoholism, reticulocytosis, metabolic disorders, drugs (5-FU, AZT, hydroxyurea) presence of round macrocytes
megaloblastic anemia a blood disorder characterized by anemia in which oval macrocytes hypersegmented neutrophil
Which hemoglobin migrates alone in cellulose acetate at an alkaline pH? HgbA and HgbF
Which hemoglobin migrates together in cellulose acetate at an alkaline pH? - HgbS, G, and D migrate to the same position - HgbC migrates with A2 and E
What causes the hemolysis associated with malarial infections? Multiplication of merozoites within erythrocytes
hemoglobin F concentration of 100% may be seen in which beta thalassemia? Delta-beta thalassemia major (dß0/dß0)
Hemoglobin H bodies can directly alter which of the following? Integrity of the RBC membrane
Which of the following methods for long-term diabetic monitoring is recommended for patients with sickle cell anemia? Fructosamine
FAB system requires ______% of non-erythroid blasts to be present in the bone marrow/peripheral blood for the classification of acute leukemia. 30%
the WHO system requires the presence of ________% non-erythroid blasts for the Classification of acute leukemia. 20%
The MOST accurate observation about osmotic pressure is that it is: Proportional to concentration of solute particles
Newborns who will develop Hemoglobin H disease may demonstrate up to 30% of which type of hemoglobin? Bart's
Lepore autosomal recessive genetic mutation leading to crosslinking of two alpha and two delta-beta chains not seen in hemoglobin H disease.
Bart's diagnostic hemoglobin in neonates for alpha thalassemia
microangiopathic anemia. Schistocytes, keratocytes, and teardrop cells
abetalipoproteinemia Acanthocytes
thalassemia findings codocytes (target)
G6PD deficiency bite cells and Heinz bodies
Acute Myelocytic Leukemia Cancer of the myeloid line of blood cells - rapid growth of abnormal white blood cells - interfere with the production of ntormal blood cells - positive Myeloperoxidase, Sudan Black B, and Chloroacetate Esterase. - target the myelocytic blast cells.
Acute Monocytic Leukemia FAB M5 Nonspecific Esterase positive (+) CD 14 , CD 64 positive (+)
Cooley's anemia beta thalassemia major which is a microcytic, hypochromic anemia.
Iron deficiency anemia microcytic, hypochromic anemia.
Pernicious anemia lack of mature erythrocytes caused by inability to absorb vitamin B12 into the bloodstream megaloblastic anemia associated with macrocytic, normochromic red blood cells.
small club-shaped, "drumstick" nuclear appendage attached to one lobe of a neutrophil (marked by the blue arrow in the image) may be found in: Normal female
causes for high eosinophil counts - Infections of parasitic helminths - Allergic reactions - Chronic Myelogenous Leukemia
Forward scatter is directly proportional to particle or cell size.
Side scatter is proportional to the surface and cytoplasmic complexity. Cytoplasmic granules and vacuoles increase side scatter.
Hydrops Fetalis Heart failure and generalized edema in the fetus secondary to severe anemia resulting from destruction of erythrocytes. Alpha thalassemia major all four alpha chain gene loci are deleted or non-functional.
Heinz bodies Intracellular inclusions seen in thalassemia, G6PD deficiency, and postsplenectomy denatured hemoglobin.
Cabot rings Mitotic spindle Remnants of microtubules
Which of the following is the cause of thrombotic thrombocytopenic purpura (TTP)? ADAMTS13 deficiency
Which of the following gene translocations is associated with Acute Promyelocytic Leukemia (APL)? t(15;17)
Multiple myeloma malignant neoplasm of bone marrow - rouleux formation due to the increased immunoglobulins present.
Aplastic anemia failure of blood cell production in the bone marrow infection, are on medication
cell markers are useful in the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH)? CD55 and CD59
hereditary hemochromatosis (HH) inherited genetic defect that causes people to absorb too much iron >45% transferrin
Alder Reilly Anomaly inability to degrade mucopolysaccharides results in an accumulation of the lipid in the cells leading to a heavily granulated appearance.
Niemann-Pick Disease. Sphingomyelinase accumulation
Gaucher Disease Beta-glucocerebrosidase
enzyme found within the granules of normal segmented neutrophils Myeloperoxidase
Alpha thalassemia intermedia Hemoglobin H disease microcytic, hypochromic anemia.
Which of the following is an FDA-approved therapeutic agent for treating sickle cell patients? Butyric acid
May-Hegglin anomaly Dohle body-like inclusions (large, blue-staining cytoplasmic inclusions), as well as bizarre/giant platelets.
abetalipoproteinemia a rare inherited disorder affecting fat absorption by the intestine and mobilization by the liver. acanthrocyte
Vitamin K dependent factors Factors II, VII, IX, and X, and proteins C, S, and Z
Which of the following forms of hemoglobin cannot be detected by routine hemoglobin methods? Sulfhemoglobin
Created by: Casey_Cee
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