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Hemo Exam 4
Leukocyte Non-Malignant Disorders
Disorder/Disease | Cause of Disorder/Disease | Type of cells invovled | Hallmark findings |
---|---|---|---|
Infectious Monoucleosis | Infection with Epstein Barr Virus | Lymphocytes | Reactive Lymphocytes/ Positive heterophile antibody |
Chronic Granulomatous Disease | Genetic disorder resulting in an inability to kat Cat+ bacteria | Neutrophils and Monocytes | Dysfunctional neutrophils containing vacuoles with bacteria |
Niemann-Picks Disease | Inherited disorder of lipid metabolism-missing sphingomyelin enzyme | Macrophages / Monocytes | Pick Cells, 1-3 Eccentric nuclei - foamy cytoplasm |
Acquired Immune Deficiency Syndrome | Viral Infections with HIV 1 or HIV 2 | T-Lymphocytes | Decreased WBC & Lymphs. More CD8 T cells than CD4 T cells |
DiGeorge Syndrome | Immune disorder that results in the attack of CD8 T-lymphs (suppressor) | T-Lymphocytes | Decreased WBC & Lymphs. More CD4 T cells than CD8 T cells |
Cytomegalovirus | Infection by herpes, DNA virus cytomegalovirus | Lymphocytes | Leukocytosis with slight Lymphocytosis-variant Positive Cytomegalo antibodies |
Alder-Reilly Syndrome | Genetic defect in metabolism of mucopolysaccharides | Granulocytes and Monocytes | Purple-Red staining granules located in WBCs |
Toxoplasmosis | Ingestion of parasite through exposure to cat feces | Lymphocytes | Increase variant Lymphocytes Positive Toxo antibodies |
Gaucher's Disease | Cellular Lipid disturbance due to b-glucocerebrosidase deficiency | Macrophages and Monocyte | Large Monocytes with 1-3 eccentric nuclei/wrinkled cytoplasm |
Bordetella Pertussuis | Bacterial Infection | Lymphocytes | Extremely high leukocytes and lymphocytes |
May-hegglin Anomaly | Genetic condition | Granulocytes | Basophilic RNA to Cytoplasmic inclusions similar to Dohle Bodies |
Chediak-Higashi Syndrome | Genetic disorder- Mutation of LYST- neutrophils cannot phagocytize because of impaired lysosomal degranulation with phagosomes. | Granulocytes | Grey-Green large cytoplasmic inclusions -Resembles Bohle Bodies |