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Hemo Exam 4

Leukocyte Non-Malignant Disorders

Disorder/DiseaseCause of Disorder/DiseaseType of cells invovledHallmark findings
Infectious Monoucleosis Infection with Epstein Barr Virus Lymphocytes Reactive Lymphocytes/ Positive heterophile antibody
Chronic Granulomatous Disease Genetic disorder resulting in an inability to kat Cat+ bacteria Neutrophils and Monocytes Dysfunctional neutrophils containing vacuoles with bacteria
Niemann-Picks Disease Inherited disorder of lipid metabolism-missing sphingomyelin enzyme Macrophages / Monocytes Pick Cells, 1-3 Eccentric nuclei - foamy cytoplasm
Acquired Immune Deficiency Syndrome Viral Infections with HIV 1 or HIV 2 T-Lymphocytes Decreased WBC & Lymphs. More CD8 T cells than CD4 T cells
DiGeorge Syndrome Immune disorder that results in the attack of CD8 T-lymphs (suppressor) T-Lymphocytes Decreased WBC & Lymphs. More CD4 T cells than CD8 T cells
Cytomegalovirus Infection by herpes, DNA virus cytomegalovirus Lymphocytes Leukocytosis with slight Lymphocytosis-variant Positive Cytomegalo antibodies
Alder-Reilly Syndrome Genetic defect in metabolism of mucopolysaccharides Granulocytes and Monocytes Purple-Red staining granules located in WBCs
Toxoplasmosis Ingestion of parasite through exposure to cat feces Lymphocytes Increase variant Lymphocytes Positive Toxo antibodies
Gaucher's Disease Cellular Lipid disturbance due to b-glucocerebrosidase deficiency Macrophages and Monocyte Large Monocytes with 1-3 eccentric nuclei/wrinkled cytoplasm
Bordetella Pertussuis Bacterial Infection Lymphocytes Extremely high leukocytes and lymphocytes
May-hegglin Anomaly Genetic condition Granulocytes Basophilic RNA to Cytoplasmic inclusions similar to Dohle Bodies
Chediak-Higashi Syndrome Genetic disorder- Mutation of LYST- neutrophils cannot phagocytize because of impaired lysosomal degranulation with phagosomes. Granulocytes Grey-Green large cytoplasmic inclusions -Resembles Bohle Bodies
Created by: Drmyette0001
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