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Neisseria

MedMicro 2006 UTHSCmed

QuestionAnswer
Neisseria characteristics Diplococcus, facultative anaerobe, oxidase (+), catalase (+), glucose fermenter, non-motile, temp = body(35-37)
N. gonorrhoeae virulence factors Pilus, antigenic/phase variation,Capsule, Protein I,II,III. LOS endotoxin activity, Iron binding protein (for gonococcal metabolism), IgA protease, beta-lactamase, Opa(invasive), Rmp(anti-antibody)
N. gonorrhoeae pathophysiology invasion thru epithelium
N. gonorrhoeae reseervoir asymptomatic carriers(humans)
N. gonorrhoeae Diseases UTI, PID, epididymitis, ophthalmia neonatorum, disseminated gonococcal infection (DGI) rare
N. gonorrhoeae specimen Exudate/swab
N. gonorrhoeae diagnosis gran tain in men (PMN diplococci), culture on Thayer-Martin medium, mucoid colonies, fastidious growth
N. gonorrhoeae Tx Ceftriaxone or spectinomycin + doxycycline(for concurrent Chlamydia)
N. gonorrhoeae Prevention/Control safe sex, condoms, follow up screen of contacts
to prevent N. gonorrhoeae(ophthalmia neonatorum) in newborns 1% silver nitrate is administered to their eyes at birth
Does N. gonorrhoeae ferment maltose Does not ferment maltose
Does N meningitidis ferment maltose? Does ferment maltose
N meningitidis virulence factors pilus colonization, specific capsule, LOS endotoxin
N meningitidis pathophysiology nosopharynx colonization, blood stream invasion
N meningitidis reservoir asymtomatic carriers (humans)
N meningitidis diseases transient bacteremia, chornic infection, acute meningitis, fulminant (Waterhouse-Friderichsen)
N meningitidis specimen lumbar puncture:w/incresed PMN's and decresed glucose
N meningitidis lab diagnosis nonselective chocolate agar, 5% CO2; fastidious growth
N meningitidis Tx penicillin G; sufonamide or rifampin for prophylaxis
N meningitidis prevention/control vaccine (serogroups A, C, Y, W135)
N meningitidis prevalent in crowded conditions; militry barracks, dorms, daycare, jails
N meningitidis serogroups B and C do what? cause meningitis and meningococcemia
N meningitidis serogroups Y and W135 do what? cause pneumonia
Where is N meningitidis serogroup A common? in 3rd world countries
What are characteristics of Acute minigitis? Abrupt onset of: fever, headache (worst of their lives), stiff neck, confusion, stupor.
for Fulminant shock administer steroids
Neisseria is the only pathogenic gram negative cocci (diplococci)
Exclusive Human disease transmitted through sexual contact Neisseria gonorrhoeae
predominantly a pediatric illness(6months-1yr) N. meningitidis
fatality rate of N. meningitidis 5-15%
N. meningitidis is aggressively, disseminated by aerosolization
Petechial lesions, headache, fever, and vomiting are diagnostic of N. meningitidis
Treatments for N. meningitidis penicillin, chemoprophylaxis(rifampin), Immunoprophylaxis
Created by: Garzilla
 

 



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