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Female Reproductive

Female Reproductive drugs

TermDefinition
Estrogen Actions: Actions: -Protecting the heart from atherosclerosis -Retaining calcium in the bones -Maintaining the secondary female sex characteristics
Estrogen Indications Indications -Hormone replacement therapy (HRT) -Palliative and preventive therapy during menopause -Replacement therapy (HRT) when ovarian activity is blocked or absent and menopause
Estrogen Drugs Estradiol (Estrace, Climara) Conjugated estrogens (Premarin) Esterified estrogen (Menest) Estropipate (Ogen)
Estrogen Pharmacokinetics Pharmacokinetics -Absorbed through the GI tract and undergoes extensive hepatic metabolism -Excreted in the urine
Estrogen Contraindications Contraindications -Allergies and pregnancy -Idiopathic vaginal bleeding, breast cancer, and estrogen -dependent cancer, thromboembolic disorders
Estrogen Caution Caution: - Breast feeding, metabolic bone disease, renal insufficiency, -hepatic impairment
Estrogen Adverse Effects Adverse Effects GI tract Systemic effects of estrogens
Estrogen Drug-Drug Interactions Drug-Drug Interactions Drugs that enhance hepatic metabolism Corticosteroids
Progestins Actions Actions -Transform the proliferative endometrium into a secretory endometrium -Inhibit the secretion of FSH and LH -Prevent follicle maturation and ovulation -Inhibit uterine contractions
Progestins Indications Indications Contraception Treatment of primary and secondary amenorrhea (the absence of menstruation) Fertility protocols
Progestins Pharmacokinetics Pharmacokinetics Well absorbed, undergo hepatic metabolism and are excreted in the urine
Progestins Contraindications Contraindications Allergies, pregnancy, idiopathic vaginal bleeding, breast or genital cancer, history of thromboembolic disorders, PID, sexually transmitted disease, endometriosis, or pelvic surgery
Progestins Adverse Effects Adverse Effects Varies based on route of administration
Progestins Drug-Drug Interactions Drug-Drug Interactions Barbiturates, Carbamazepine, Phenytoin, or Rifampin
Progestins Drugs Plan B One Step Norethindrone Acetate
Estrogen Receptor Modulators Drugs Raloxifene (Evista) Toremifene (Fareston)
Estrogen Receptor Modulators Actions Actions Modulating effects on estrogen receptors Used to stimulate specific estrogen receptors to increase bone mineral density
Estrogen Receptor Modulators Indications Indications Postmenopausal osteoporosis
Estrogen Receptor Modulators Pharmacokinetics Pharmacokinetics Well absorbed in the GI tract, metabolized in the liver Excreted in the feces
Estrogen Receptor Modulators Contraindications Contraindications Known allergy Pregnancy / lactation Hx of venous thrombosis or smoking
Estrogen Receptor Modulators Adverse Effects Adverse Effects GI upset Changes in fluid balance: headache, dizziness, and visual changes Estrogen receptor stimulation: hot flashes, skin rash, edema, and vaginal bleeding
Estrogen Receptor Modulators Drug-drug interactions Drug-drug interactions- Cholestyramine Diazepam (Valium) Ibuprofen (Motrin) Indomethacin (Indocin) Naproxen (Naprosyn) Warfarin
Created by: garmijos
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