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Musculoskeletal

MUSCULOSKELETAL 1-2

Generic NameBrand NamePharmacological CategoryCommon IndicationsKey Side EffectsUS Boxed WarningsOther Notes
colchicine (PO) Colcrys Antigout agent Gout diarrhea, nausea, vomiting, bone marrow suppression, myotoxicity (including rhabdomyolysis)
diclofenac (PO) Voltaren NSAID OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
ibuprofen (PO) Motrin, Advil NSAID OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
meloxicam (PO) Mobic NSAID OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
nabumetone (PO) Relafen NSAID OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
piroxicam (PO) Feldene NSAID OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
indomethacin (PO) Indocin NSAID OA, RA, acute pain, gout diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
naproxen (PO) Naprosyn, Anaprox NSAID OA, RA, acute pain, gout diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
ketorolac (PO, IV) Toradol NSAID Pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea indicated for short term use (≤ 5 days) may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
celecoxib (PO) Celebrex NSAID, COX-2 selective OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
diclofenac (topical) Voltaren Gel, Solareze NSAID OA pruritus, rash
cyclobenzaprine (PO) Flexeril Skeletal muscle relaxant Muscle spasm drowsiness, dizziness, xerostomia, fatigue use may cause prolonged cardiac, arrhythmias, and tachycardia; CI within 14 days of MAOI inhibitor therapy
baclofen (PO) Lioresal Skeletal muscle relaxant Spasticity drowsiness
carisoprodol (PO) Soma Skeletal muscle relaxant Muscle spasm drowsiness drug abuse potential (carisoprodol only)
methocarbamol (PO) Robaxin Skeletal muscle relaxant Muscle spasm drowsiness
metaxalone (PO) Skelaxin, Metaxall Skeletal muscle relaxant Muscle spasm drowsiness
orphenadrine (PO) Norflex Skeletal muscle relaxant Muscle spasm drowsiness, dizziness, xerostomia, fatigue use caution in patients with cardiac disease
bupivacaine (IV) Marcaine, Sensorcaine Local anesthetic Epidural anesthesia hypotension bupivacaine 0.75% should not be used for obstetrical anesthesia due to reports of cardiac arrest and death ISMP-high alert medication
lidocaine (transdermal, IV) Transdermal: Lidoderm IV: Xylocaine Transdermal: topical analgesic IV: antiarrhythmic Transdermal: pain IV: ventricular arrhythmias dermatitis, erythema, urticaria, skin depigmentation, skin edema bradycardia ISMP-high alert medication (IV), patch may remain in place for up to 12 hours in any 24-hour period, patch may be cut
allopurinol (PO) Zyloprim Xanthine oxidase Inhibitor Gout diarrhea, nausea, rash, leukopenia, thrombocytopenia rare association with severe (and potentially fatal) allopurinol hypersensitivity syndrome (risk highest in certain Asian populations)
succinylcholine (IV) Anectine Depolarizing neuromuscular blocking agent Neuromuscular blockade for intubation or procedures hyperkalemia, myalgia, malignant hyperthermia (rare) acute rhabdomyolysis and hyperkalemia leading to cardiac arrest and death in pediatric patients with undiagnosed skeletal muscle disease ISMP-high alert medication
tizanidine (PO) Zanaflex Alpha2 agonist Spasticity drowsiness, hypotension, dizziness, xerostomia, weakness
hydroxychloroquine (PO) Plaquenil Aminoquinoline RA, SLE, malaria retinal toxicity, rash, diarrhea use has been associated with cardiomyopathy, bone marrow suppression, and neuromuscular effects (i.e., myopathy, palsies, and progressive weakness)
Created by: lnduta
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