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Embryo week 4

The early heart develops in the 3rd week from _____ endcardial tubes in the cardiogenic region
The cardiogenic region is located cranial to the ______ before embryo folding, but lies caudal to the mouth and ventral to the foregut after the embryo folds. oropharangeal membrane
Late in the 3rd week, the endocardial tubes develop into the ______. This early heart joins with newly formed blood vessels to create a ______ primordial heart primordial cardiovascular system
Blood begins to circulate and the heart beat in the ______. This is the first organ system to become functional in the embryo 4th week (day 21-22).
Blood vessels develop by two processes: _______ vasculogenesis and angiogenesis
______ is the formation of new vessels by the aggregation of _____ (vessel forming cells) into clusters called ______ Vasculogenesis Angioblasts Blood islands
Cavities appear in the blood islands. The ______ flatten and differentiate into endothelial cells which line the new vessel. ______ line all blood vessels in both the embryo and adult. Angioblasts Endothelial Cells
______ coalesce to form the major blood vessels Yolk sac blood islands -> vitelline vessels Umbilical blood islands -> umbilical vessels Blood islands in the embryo -> major vessels (aorta, cardinal veins) Blood islands
New vessels sprout off preexisting vessels by ______ which allows the cardiovascular system to expand as the embryo grows. Angiogenesis
______, the formation of blood cells, begins in the 3rd week and continues through out life. Hematopoiesis
Blood cells first develop from _____ in blood islands of the _____ Endothelial Cells Yolk Sac
_______ shifts to other organs as the embryo develops: _______ to the _____, then ______ and _____ followed by the _____ (the site of adult hematopoesis). Hematopoiesis Yolk Sac liver thymus spleen bone marrow
_______ are formed from different progenitor cells. They are named after the different _____ in the hemoglobin molecule: _____: Hemoglobin z2e2 _____: Hemoglobin a2g2, _____: Hemoglobin a2b2 Fetal and adult erythrocytes Globin subunits Embryonic Fetal Adult
Fetal erythrocytes and hemoglobin are present for _____ after birth by which time only the adult form is found. 6-7 months
Development of the embryo from a flat disk into a tube requires _____ folding in both the cranio-caudal and lateral directions.
Folding results from ______. This causes the upper layer to grow faster and bend the embryo towards the lower surface of the disk. unequal proliferation of cells on the upper surface of the disk
The _____ result from the elongation of the embryo in the craniocaudal direction. Elongation is mainly from growth of the nervous system. head and tail folds
Folding in the ____ region causes the septum transversum (primordial diaphragm), and the cardiogenic region to move from a cranial position to lie caudal to the oropharangeal membrane (mouth) and ventral to the foregut. head septum traversum (primordial diaphragm) cardiogenic region oropharangeal membrane (mouth)
Created by: sobe0015