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pharm-coag

pharmacology of coagulation

QuestionAnswer
clopidogrel reduce platelet aggregation by inhibiting ADP pathway of platelets
clopidogrel used rot TIA, CVA and unstable angina
clopidogrel anti-platelet effect lasts for 7-10 days
heparin increases activity of antithrombin
heparin releases lipoprotein lipase
heparin used as prophylaxis for DVT; and to treat MI and PE
heparin adverse effects--> bleeding, thrombocytopenia, hypersensititvity, reversible alopecia, osteoporosis
heparin contraindications--> active bleeding, hemophilia, thrombocytopenia, HTN, purpura, before and after brain, spinla cord or eye surgery; no apirine, use caution during pregnancy
coumadin highly teratogenic and fetotoxic
coumadin clotting factors cannot bind Ca; blocks vit. K; factors II, VII, IX, X
coumadin prohpylaxis of DVT's and PE's; A-fib
coumadin adverse effects--> bleeding, hemorrhagic infarct in breast, intestine and fatty tissue
coumadin interactions--> phenylbutazone and sulfinpyrazone- displaces from albumin; ASA- increases the action of coumadin; antibiotics- decreases vitamin K; barbituates and rifampin; decrease the effectiveness; oral contraceptives- decrease warfarin effectiveness
desmopressin acetate increases factor VIII activity and can be used before minor surgeries in patients with mild hemophelia A
ASA decreases thromboxane A2 production
ASA reduce antithromotic action by decreasing endothelial cell synthesis of PGI2
Created by: swohlers
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