click below
click below
Normal Size Small Size show me how
Pulmonary
FA complete review part 4 Pharmacology
Question | Answer |
---|---|
What is the mechanism of action of Histamine-1 blockers? | Reversible inhibitors of H1 histamine receptors. |
What are some First generation H1-blockers? | Diphenhydramine, dimenhydrinate, and chlorpheniramine. |
What are the clinical uses for H1-blockers? | Allergy, motion sickness, and sleep aid |
What are common side effects of H1-blockers? | Sedation, antimuscarinic, anti-alpha-adrenergic. |
What are some examples of Second generation H1-blockers? | Loratadine, fexofenadine, desloratadine, cetirizine. |
What is the main use for H1-blockers of second generation? | Allergy |
Why are second generation far less sedating than 1st generation H1-blockers? | Less entry into CNS |
Common expectorant? | Guaifenesin |
What is N-acetylcysteine? | Mucolytic- liquifies mucus in chronic bronchopulmonary diseases by disrupting disulfide bonds. |
N-acetylcysteine is used for antidote for ____________________ overdose. | Acetaminophen |
What is Dextromethorphan mechanism of action? | Antitussive; antagonizes NMDA glutamate receptors; Synthetic codeine analog. |
How can Dextromethorphan overdose treated? | Naloxone |
What is a significant adverse effect of Dextromethorphan? | Serotonin syndrome if combined with other serotonergic agents. |
What is the mechanism of action of Pseudoephedrine and Phenylphrine? | a-adrenergic agonists, used as nasal decongestants |
What are the clinical uses for Pseudoephedrine and phenylephrine? | 1. Reduce hyperemia, edema, and nasal congestion 2. Open obstructed eustachian tubes |
What are the most significant adverse effects of Pseudoephedrine and phenylephrine? | 1. Hypertension 2. Rebound congestion if used more than 4-6 days 3 CNS stimulation/anxiety (pseudoephedrine) |
What drug categories are used in the treatment of Pulmonary hypertension? | 1. Endothelin receptor antagonists 2. PDE-5 inhibitors 3. Prostacyclin analogs |
What is the MOA of Endothelin receptor antagonists? | Competitively antagonizes endothelin-1 receptors --> decrease in pulmonary vascular resistance |
Which endothelin receptor is blocked by Endothelin-receptor blockers? | Endothelin-1 |
What is the most common example of an Endothelin-receptor antagonist? | Bosentan |
Bosentan is an _______________________________. | Endothelin-receptor antagonists |
What is the associated adverse effect of Bosentan? | Hepatotoxic (monitor LFTs) |
What is the MOA of PDE-2 inhibitors? | Inhibits PDE-5 --> Increase in cGMP, which as result causes prolonged vasodilatory effect of NO (nitric monoxide). |
Besides management of Pulmonary HTN, another common use for PDE-5 inhibitors is _____________________. | Erectile dysfunction |
What drugs/compounds are contraindicated in a patient on PDE-5 inhibitors? | Nitroglycerin or other nitrates |
What is the most common example of PDE-5 inhibitor? | Sildenafil |
What are the examples of Prostacyclin analogs? | Epoprostenol, iloprost |
MOA of Prostacyclin analogs | -PGI2 (prostacyclin) with direct vasodilatory effects on pulmonary and systemic arterial vascular beds - Inhibits platelet aggregation. |
What are the most common side effects of Prostacyclin analogues? | Flushing and jaw pain |
Asthma therapy is directed to counteract which two processes of Bronchoconstriction? | 1. Inflammatory processes 2. Parasympathetic tone |
Short acting B2 agonist | Albuterol |
What are 3 common B2-agonists used in Asthma treatment? | Albuterol (short acting), Salmeterol, and formoterol |
What is the common B2-agonist used in acute exacerbation of asthma? | Albuterol |
What is MOA of Albuterol? | Relaxes bronchial smooth muscle in acute setting. |
Which B-2 agonists are commonly used a prophylaxis of Asthma? | Salmeterol and Formoterol |
What are common adverse effects of Salmeterol? | Tremor and arrhythmias |
Examples of common inhaled corticosteroids? | Fluticasone and Budesonide |
What Asthma drugs are known to inhibit the synthesis of virtually all cytokines? | Inhaled corticosteroids (fluticasone, budesonide) |
What drug(s) are the first line of treatment for chronic asthma ? | Inhaled corticosteroids (fluticasone, budesonide) |
What is the mode action of Fluticasone? | Inactivate NF-KB |
What is the function of NF-KB? | Transcription factor that induces production of TNF-alpha and other inflammatory agents |
What transcription factor is inactivated by inhaled corticosteroids, such as Fluticasone? | NF-KB |
What actions must be taken in order to prevent oral thrush formation from the use of Fluticasone and other inhaled corticosteroids? | Use a spacer or rinse mouth after use |
Which are two common Muscarinic antagonists? | Tiotropium and Ipratropium |
What is the MOA of Muscarinic antagonist? | Competitively block muscarinic receptor, preventing bronchoconstriction. |
Tiotropium and Ipratropium are ______________ _______________. | Muscarinic antagonists |
Which muscarinic antagonist is used in treatment of asthma and is known to be long-acting? | Tiotropium. |
3 common antileukotrienes: | Montelukast, Zafirlukast, and ZIleuton |
Which antileukotrienes block leukotriene receptors CysLT1? | Montelukast and Zafirlukast |
What are the recommended asthma drugs for Aspirin-induced asthma and Exercise-induced asthma? | Montelukast and Zafirlukast |
Montelukast and Zafirlukast are _______________________-. | Antileukotrienes |
5-lipoxygenase pathway inhibitor. | Zileuton |
What is blocked by the use of Zileuton? | Conversion of arachidonic acid to leukotrienes |
Which antileukotriene is known to be hepatotoxic? | Zileuton |
What is Omalizumab? | Anti-IgE monoclonal antibody in the treatment of asthma |
What is the mode of action of Omalizumab? | Binds unbound serum IgE and blocks binding to FcERI |
What type of asthma is the one that most commonly uses Omalizumab as part of drug therapy? | Allergic asthma with elevated IgE levels resistant to inhaled steroids and long-acting B2-agonist |
Patient's asthma proven ineffective treatment with inhaled steroids and Salmeterol, may be given _______________ as therapy for asthma. | Omalizumab |
Theophylline is a __________________________. | Methylxanthine |
How does Theophylline causes bronchodilation? | By inhibiting phosphodiesterase --> elevated cAMP levels due to decreased cAMP hydrolysis |
Why is the use of Theophylline limited? | Due cardiotoxicity and neurotoxicity |
Theophylline blocks actions of _______________. | Adenosine |
Theophylline is metabolized by the ________________________. | CYP450 system. |
What are common examples of Mast cell stabilizers? | Cromolyn and nedocromil |
Mechanism of action of Mast cell stabilizers | Prevent release of inflammatory mediators from mast cells |
What is the main use for mast cell stabilizers? | Prevention of bronchospasm |
Which Asthma drugs are used to prevent/treat symptoms? | 1. B-agonists 2. Theophylline 3. Muscarinic antagonists |
Which Anti-asthmatic drugs are used for prevention or treatment of bronchial hyperreactivity? | Studies and Antileukotrienes |
What is the early response of asthma process? | Bronchoconstriction --> symptoms |
What is the late response of asthma? | Inflammation --> bronchial hyperreactivity. |