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Hematology Exam 4.
Non-Malignant Leukocyte Disorders
Disorder/Disease State | Cell(s) Involved | Cause of Disorder/Disease | Major Lab Findings |
---|---|---|---|
Neimann-Picks Disease | Macrophages / Monocytes | Inherited disorder of lipid metabolism-deficient of enzyme spingomyelin | Pick cells, 1-3 eccentric nuclei w/ foamy cytoplasm |
Acquired Immune Deficiency Syndrome | T Lymphocytes | Viral Infection w/ HIV-1 or HIV-2 | ↓ WBC/Lymphs , More CD-8 T Cells than CD-4 T Cells |
DiGeorge's Syndrome | T Lymphocytes | Immune Disorder that results in the attack of CD8 T-Lymphs | ↓ WBC/Lymphs, More CD-4 T Cells than CD-8 Cells |
Cytomegalovirus | Lymphocytes | Infection by Herpes, DNA virus cytomegalovirus | Leukocytosis w/ slight Lymphocytosis |
Alder-Reilly Syndrome | Granulocytes/Monocytes | Genetic defect in metabolism of mucopolysaccharides | Purple-Red staining of granules |
Gaucher's Disease | Macrophages/Monocytes | Cellular lipid disturbance due to b-glucocerobrosidase deficiency | Large monocytes w/ 1-3 eccentric nuclei w/ wrinkled cytoplasm |
Toxoplasmosis | Lymphocytes | Ingestion of parasite through exposure to cat feces | ↑ Variant Lymphs + Toxo antibodies |
Bordetella Pertussuis | Lymphocytes | Bacterial Infection | ↑ Leukocytosis, ↑Lymphocytosis |
May-Hegglin Anomaly | Granulocytes | Genetic Condition | Basophilic RNA cytoplasmic inclusions = Dohle Bodies |
Chediak-Higashi Syndrome | Granulocytes | Genetic Disorder-Mutation of LYST-Neutrophils cannot phagocytize | Grey-green large cytoplasmic inclusions resemble Dohle Bodies |
Infectious Mononucleosis | Lymphocytes | Infection with Epstein Barr Virus | Reactive Lymphocytes & + Result to Heterophil Antibody |
Chronic Granulatomous Disease | Neutrophils & Monocytes | Genetic Disorder resulting in an ability to kill catalase+ bacteria | Dysfunctional neutrophils contains vacuoles w/ bacteria |