click below
click below
Normal Size Small Size show me how
Toxicology & TDM
Into to toxicology
Question | Answer |
---|---|
define toxicology | the study & science of poisons & poisonings |
substance that when used in small amounts is injurious to health or dangerous to life | Poison |
the degree of poisonous hazard present by a given substance | Toxicity |
Minimal Lethal Dose (MLD) is defined as | the smallest amt of a substance that will cause death |
Minimal Lethal Dose (MLD) -rating from 1-6....what is practically nontoxic to super toxic | 1-practically non toxic 2- slightly 3- moderately 4- very 5-extremely 6-super toxic |
Most common routes of exposures are | ingestion,inhalation and transdermal absorption |
Acute toxicity | single, short-term exposure to a substance |
Repeated, frequent exposure for extended periods of time is know as: Acute or Chronic Toxicity? | Chronic |
DEA class drugs [I] Examples -no accepted medical use in the US and a high potential for abuse | heroin LSD PCP mescaline marijuana |
DEA class drugs [II] Examples -high abuse potential w/ severe pyschic or physical dependence | opium codeine hydromorphone |
DEA class drugs [III] Examples -less potential for abuse than I or II; limited amts of narcotics | Doriden Nodeular |
DEA class drugs [IV] Examples -less than class III | barbiturates benzodiazapines |
DEA class drugs [V] Examples -less than class IV; limited narcotic concentration | antidiarrheal medicine |
Analysis of toxic agents: two-step procedure 1. Screening: has good analytic ____ but lacks ____ 2. Confirmatory | Screening: good sensitivity but lacks specificity Confirmatory: confirms screening |
Contaminated or adulterated samples may cause | erroneous results that lead to significant consequences |
Urine Adulteration Test Strip-Intect 7 CNGPSBP | Creatinine Nitrite Glutaraldehyde pH Specific Gravity Bleach Pyridinium chlorochromate |
Drugs of Abuse: Hypnotics & sedatives -f[x] & examples | calm or produce sleep barbiturates, benzodiazapine, doriden |
Drugs of Abuse: Analgesics -f[x] & examples | reduce or eliminate pain narcotic: morphine non narc: aspirin, acetaminophen |
Drugs of Abuse: Stimulants -f[x] & examples | work on CNS & produce excitation -amphetamine, caffeine, nicotine, cocaine |
Drugs of Abuse: Antidepressants -f[x] & examples | control anxiety tricylic compounds |
Drugs of Abuse: Tranquilizers -f[x] & examples | lower anxiety benzos,phenothiazines, carbamates |
Drugs of Abuse: Psychotoxic -f[x] & examples | produce euphoria or hallucinations Class I drugs: PCP or LSD |
Drugs of Abuse: Antihistamines -f[x] | block action of histamines--cause drowsiness and coma in overdose |
Drugs of Abuse: Antionvulsants -f[x] & examples | depress CNS to prevent seizures Phenobarb, Dilantin |
Drugs are classified by | salt forming ability |
Acidic drug forms salt w/ bases i.e______ | Sodium Phenobarb |
Basic drug forms salt w/ acids i.e____ | Ephederine HCL |
Neutral drugs do not form salts w/ either bases or acids i.e____ | Meprobamate & Glutethimide |