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CJD/vCJD TTI
CJD and blood transfusion safety
Question | Answer |
---|---|
Clinical course of patients diagnosed with CJD or CJD | uniformly fatal, and no treatment is available |
Describe effect of pathogen reduction technologies on vCJD risk | None |
Routes of transmission for vCJD | food-borne (Mad cow disease) and transfusion |
This mutation of the PRNP gene is common in transfusion transmitted cases of vCJD | 129MM (methionine homozygous at codon 129 (129MM) of the PRNP gene) |
Number of documented cases of sporadic CJD transmitted by transfusion | None |
Two countries with the most vCJD cases | UK and France (89% of cases; 215 cases of 241 total cases) |
All 4 blood transfusion related cases of vCJD were from these products | non-leukoreduced RBCs |
How many cases of transfusion transmitted vCJD have been reported outside of the UK? |