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Hematology
Chronic Leukemias
Name | Main Characteristics |
---|---|
Chronic Monocytic | Gradual, enlarged, lymph nodes & spleen (also pain) Leukopenia Increased numbers of large mature monocytes w convoluted, indented or irregular nuclei and cytoplasmic pseudopods Moderate decrease in platelets |
Chronic Lymphocytic - B Cell | Normal bone marrow get infiltrated by excessive production of mature lymphocytes Often asymptomatic w detection at a routine physical Leukocytosis = 30 - 200x10^9/L CD5, CD22, CD24 |
Chronic Lymphocytic - T Cell | Normal bone marrow get infiltrated by excessive production of mature lymphocytes Often asymptomatic w detection at a routine physical Leukocytosis = 30 - 200x10^9/L CD2, CD3, CD8 |
Prolymphocytic | Seen in older men B-cell disease w poor prognosis Large numbers of prolymphocytes with smooth nuclear chromatin & large nuclei |
Hairy Cell | Predominance of B Lymphs that demonstrate phagocytic characteristics Fine hair like cytoplasmic projections |
Multiple Myeloma | Hyperproliferation of one type of immunoglobulin Increased number of plasma cells in peripheral blood RBC rouleaux formation & increased sedimentation rate Bence Jones protein in urine (50% of patients) |
Waldenstrom’s Primary Macroglobulin | Plasma cell proliferative disorder Uncontrolled proliferation of lymphocytes & plasma cells Greater degree of maturation of B Lymphs to Plasma cells Chronic anemia & bleeding episodes IgM Thrombocytopenia cytoplasm that is ragged |