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Melanocytes and Nevi

Lentigo in sun damaged skin with increased number of melanocytes
Peutz Jeghers syndrome lentigo accumulate in the perioral distribution and hands and feet
Ephelis like lentigo only they darken in the sun and have the same number JUST more melanin production
Cafe Au Lait Look like freckles but larger
Neurofibromatosis if more than six cafe au laits that is diagnostic
Three Types of NEVI (moles) Junctional (dermal-epidermal layer) Compound (junction and dermis) and Intradermal (confined in the dermis)
Spitz Nevus aka spindle and epitheliod cell Nevus seen mostly in children
Blue Nevus Collection of pigmented dendritic melanocytes in the dermis common on butt, face, feet and dorsa of the hand
Cong. Nevus Small to Giant in Size can involve large areas of the body and are at risk for developing Malignant melanoma risk
Where do malignant melanomas occur anywhere
Median age for dev. a malignant melanoma 50
who gets malignant melanomas light skinned people with incidental exposure
what is the 5 year with malignant melanoma 80%
where is the highest incidence of malignant melanoma australia
how do almost all Malignant melanomas begin as an abnormal proliferation of malanocytes within the epidermis (in situ)
what are the two growth patterns of malignant melanoma vertical and Radial
Radial Growth confined within the epidermis if they drop into the papillary dermis they are eliminated at once
cellular appearance of malignant melanocytes irregular and atypical
Clark system of measurment Level 1- intraepidermal 2-papillary dermis 3-fills papillary dermis 4-subcutis invasion
Breslow's thickness Measurement 90-95% prognostic Less than .75 mm never and more than 4mm 60% mets
besides clark and breslow what are some other indicators for survival women > men and extremities> other sites
what are the classifications of malignant melanomas Superficial, Lentico, Acral, Nodular
Superficial spreading Malignant melanom 70% of malignants are superficial Legs of women and backs of men LONG radial phase until vertical phase starts signified by a nodule
Lentigo Malig. melanoma in sun exposed, usually on the face, Long Radial Phase (10-40 yrs)
Nodular malignant Melanoma 10-15% VERY short undetectable radial growth phase, evolves as a nodule from the start
Acral Lentiginous Melanoma Most common in African, Asian, Hispanics, Native Amer on palms and soles, or mucus membranes irregular borders adn varying colors with some radial before vertical BY FAR THE RAREST
how are melanocytes identified S-100 proteins and Malanosomes
Created by: jmuame03