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laurate 12:0 fatty acid
myristate 14:0 fatty acid
stearate 18:0 fatty acid
arachidate 20:0 fatty acid
oleate 18:1 ω9 fatty acid
Linoleate 18:2 ω6 fatty acid
Linolenate 18:3 ω3 fatty acid
general steps of beta-oxidation oxidation, hydration, oxidation, thiolysis
energy requirement for activation of CoA ester -2 ATP
acetoacetate ketone body
B-hydroxybutyrate ketone body
acetone ketone body
B-hydroxy-B-methylglutaryl-CoA precursor for ketone body formation
arachidonic acid 20:4 n-6
chylomicron apoproteins A-1, B-48, C-II, E
LDL apoproteins B-100,
VLDL apoproteins B-100, C-II, E
IDL apoproteins B-100
HDL apoproteins A-1, C-II, E
energy production per step of B-oxidation 1 NADH 1 FADH2 1 Acetyl CoA
palmitate 16:0 Fatty acid
C10 unit in cholesterol production geranyl pyrophosphate
C15 unit in cholesterol production farnesyl pyrophosphate
C30 unit of cholesterol production squalene
Sandhoff's disease Hexosaminidase A & B deficiency
Krabbe's disease Galactosyl ceramide B-galactosyl hydrolase
Tay-Sachs disease Hexosaminidase A deficiency
Fabry's disease a-Galactosidase deficiency
Gaucher's disease B-Glucosidase deficiency
Niemann-Pick disease Sphingomyelinase deficiency
Eicosanoids leukotrienes and lipoxins prostaglandins thromboxanes prostacyclins
leukotrienes Formed from arachidonate through the enzyme lipoxygenase LTB4, LTC4, LTD4, LTE4, LTA4
prostaglandins PGI2, PGE2, PGF2a
cyclooxygenase Enzyme responsible for forming prostanoids. Inhibited by Aspirin, Acetominaphen, Ibuprofen, Celebrex
Thromboxanes TXA2 Promotes platelet aggregation Produced mostly by platelets Decreases cAMP production
metachromatic leukodystrophy sulfatase
LTB4 Leukotriene Increased leukocyte chemotaxis Release of lysosomal enzymes Aggregation of white blood cells Bronchoconstriction
PGI2 Prostaglandin Vasodilation Inhibits platelet aggregation Produced primarily by vessel endothelium
TXA2 type of Thromboxane Promotes plately aggregation Produced mostly by platelets Decreases cAMP production
lipoxygenase enzyme that converts arachidonic acid to leukotrienes
prostanoids Formed from arachidonate through the enzyme cyclooxygenases. Further classified into prostaglandins, thromboxanes, and prostacyclins
Created by: amybemt