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Hyperlipidemia II
Stuff
Question | Answer |
---|---|
SREBP-SCAP | transcription factor increases LDL receptors |
LXR-RXR | increases conversion to bile, reverse transport, and SREBP1c so TGs are mde not cholesterol |
FXR-RXR | Increased bile export decreased synth |
PPAR-alpha-RXR | increase lipoprotein lipase (VLDL met) and increase fatty acid oxidation in the liver (decreased VLDL synth) |
lipoprotein lipase recognizes? | Apo CII |
VLDL steals ? from HDL | CE, APOC II-III and ApoE |
how do small denses LDL form | hepatic lipase removes more TGs from LDL |
how is discoid HDL made | ApoA I and II from the liver and the gut |
how does HDL dock with the hepatocytes | SRBI |
ABC transport does? | takes CE from the cells and gives it to HDL |
what does CETP do? | takes CE from HDL and gives it to VLDL and LDL |