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Micro 6-2
Duke PA micro
| Question | Answer |
|---|---|
| I (porin) | increase intracellular survival |
| II (opacity) | mediates attachment to host epithelial cells |
| III (reduction-modifiable) | prevents cidal action of serum |
| Is N. gonorrhoeae capable of intracellular survival? | yes |
| How is diagnosis of N. gonorrhoeae made? | shows up on Gram stain of urethral discharge, but diagnosis is now usually made by genetic amplification |
| N. gonorrhoeae grows optimally in what conditions? | at 37 degrees C, in presence of small amount of carbon dioxide |
| Who provides reservoir for N. gonorrhoeae infection? | asymptomatic women - transmission can occur perinatally |
| roughly 2% of N. gonorrhoeae infections disseminate | blood, skin, joints (females, knees) |
| Monoarticular arthirits of the knee in sexually active young woman points toward infection with what? | N. gonorrohoeae |
| N. meningitidis survival? | encapsulated, like N. gonorrhoeae can survive intracellularly |
| How is nasopharynx colonized with N. meningitidis? | receptors in nasopharynx allow colonization by meningococcal pili |
| What percent of population is colonized with N. meningitidis? | roughly 10 percent |
| How is N. meningitidis spread? | by direct contact or respiratory droplet |
| What develops as result of hematogenous spread of N. meningitidis? | meningitis, is endemic in 0-5 years, peaks again in late adolescence |
| What mediates signs/symptoms in meningitis caused by N. meningitidis? | endotoxin |
| What is equally as fastidious as N. gonorrhoeae? | N. meningitidis |
| Pasturella multocida - gram positive or negative? | gram negative coccobacillus |
| What are natural reservoirs of Pasturella multocida? | cats/dogs |
| Transmission of Pasturella multocida? | zoonotic - via bita, scratch, or licking of open wounds |
| Virulence factors of Pasturella multocida | polysaccharide capsule, endotoxin |
| Pasturella multocida - aerobic or anaerobic? | aerobic |
| Veillonella spp. Gram negative or positive? | gram negative cocci |
| Veillonella spp. Aerobic or anaerobic? | anaerobic |
| Veillonella normal flora | mouth, GI and female genital tract |
| How common are infections with Veillonella? | rare in immunocompetent hosts |
| Veillonella infection | rare, but serious when they occur and include osteomyelitis (most common), meningitis, and endocarditis |
| Kingella kingae - gram positive or negative | negative, small coccobacilli, resembles Neiserria |
| Kingella kingae - aerobic or anaerobic? | anaerobic |
| Kingella kingae normal flora | human oropharynx |
| most common species of Kingella? | K. kingae - first described in 1960s by Elizabeth King |
| K. kingae infection | most commonly involve the feumr, talus or calcaneus (other sites include lower respiratory tract, blood stream and heart valves) |
Created by:
ges13
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