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Micro 6-2

Duke PA micro

I (porin) increase intracellular survival
II (opacity) mediates attachment to host epithelial cells
III (reduction-modifiable) prevents cidal action of serum
Is N. gonorrhoeae capable of intracellular survival? yes
How is diagnosis of N. gonorrhoeae made? shows up on Gram stain of urethral discharge, but diagnosis is now usually made by genetic amplification
N. gonorrhoeae grows optimally in what conditions? at 37 degrees C, in presence of small amount of carbon dioxide
Who provides reservoir for N. gonorrhoeae infection? asymptomatic women - transmission can occur perinatally
roughly 2% of N. gonorrhoeae infections disseminate blood, skin, joints (females, knees)
Monoarticular arthirits of the knee in sexually active young woman points toward infection with what? N. gonorrohoeae
N. meningitidis survival? encapsulated, like N. gonorrhoeae can survive intracellularly
How is nasopharynx colonized with N. meningitidis? receptors in nasopharynx allow colonization by meningococcal pili
What percent of population is colonized with N. meningitidis? roughly 10 percent
How is N. meningitidis spread? by direct contact or respiratory droplet
What develops as result of hematogenous spread of N. meningitidis? meningitis, is endemic in 0-5 years, peaks again in late adolescence
What mediates signs/symptoms in meningitis caused by N. meningitidis? endotoxin
What is equally as fastidious as N. gonorrhoeae? N. meningitidis
Pasturella multocida - gram positive or negative? gram negative coccobacillus
What are natural reservoirs of Pasturella multocida? cats/dogs
Transmission of Pasturella multocida? zoonotic - via bita, scratch, or licking of open wounds
Virulence factors of Pasturella multocida polysaccharide capsule, endotoxin
Pasturella multocida - aerobic or anaerobic? aerobic
Veillonella spp. Gram negative or positive? gram negative cocci
Veillonella spp. Aerobic or anaerobic? anaerobic
Veillonella normal flora mouth, GI and female genital tract
How common are infections with Veillonella? rare in immunocompetent hosts
Veillonella infection rare, but serious when they occur and include osteomyelitis (most common), meningitis, and endocarditis
Kingella kingae - gram positive or negative negative, small coccobacilli, resembles Neiserria
Kingella kingae - aerobic or anaerobic? anaerobic
Kingella kingae normal flora human oropharynx
most common species of Kingella? K. kingae - first described in 1960s by Elizabeth King
K. kingae infection most commonly involve the feumr, talus or calcaneus (other sites include lower respiratory tract, blood stream and heart valves)
Created by: ges13