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Pathology 3-3

Duke PA pathology

Which mechanisms of disease caused by tumors cause pain? tissue destruction, organ compression
Staging catergorizes malignant tumors based on what? potential for invasion and metastasis
Tumor grading is based on what? histologic examination of the tumor, provides estimated degree of malignancy
TMN system tumor staging
T in TMN system reflects size of tumor
N in TMN system reflects lymph node involvement
M in TMN system reflects the extent of metastasis
In tumor staging, which number indicates a better prognosis? lower
Who performs tumor grading? pathologist
Is grading system the same for all tumors? no - differs according to tumor type
Grade I tumor well-differentiated, low anaplasia
Grade II, III tumor intermediate differentiation
Grade IV tumor poorly differentiated; high anaplasia
Major therapeutic modalities for cancer surgery, radiation, chemo, immunotherapy, molecularly-based therapy, combination therapy
What is the 3rd most common cancer in incidence and mortality? colorectal cancer
What percent of colorectal cancer has hereditary component? 15-50 percent
What percent of colorectal cancer is due to known mutations? roughly 15 percent - FAP, HNPCC
Can tobacco cause colon cancer? yes
Created by: ges13