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rsrch pharm 2-6

respiratory

DECONGESTANTSDextromethorphan (VicksFormulaEXPECTORANTSGuaifeniesin (Robitussi, HumabBRONCODILATORSXANTHINE DERIVATIVESTheophylline (Theo- Dur, Slo
adrenergic agents- constrict small arteriolestaht supply the structures of the upperrespiratotory tract. nonopiod antitussive cough reflex stimulation or direct stimulation of the secretory glands in the repiraotyr tract. EXPECTORANT xanthine and beta agonists bronchodialation by increasing the levles of energy producing substance cAMP xanthine
contraindicated in pts with diabetes, hypertension, cardiac disease, throid dysfunction nonaddiction and does not cause CNS depression used for productive cough thins difficult to cough up mucus in respiratory tract. increase level of cAMP by inhibiting enzyme that breaks down cAMP = alveolar stay open caffiene tx of chronic respiratory disorders ; relief of mild to moderate acute
constric sm artioles; anticholinergic; cortocosteriods- rarely used -aimed at inflammatory repsonse Adverse effects Respiratory: Respiratory depression (with overdose) MOA- 1.) reflex of stimulation by loosening and thinning rspt secretions 2.)dirct stimulation of secrtory glands Adverse effects CNS: Headache, dizziness Dermatologic: Rash, urticaria GI: Nausea, vomiting, GI discomfort tx for dmphaysem and chronic bronchitis relatively slow onset- used for prevention of asthma attacks increased metabolization in liver = incrased interactis and toxitiy
3 routes- 1.)intranasally, 2.)orally, 3.topically Lacks analgesic and addictive properties; controls cough spasms by depressing the cough center in the medulla; analog of codeine. cough reflex stimulation or direct stimulation of the secretory glands in the repiraotyr tract. Indications Symptomatic relief of respiratory conditions characterized by dry, nonproductive cough and in the presence of mucus in the respiratory tract. SE- nauses, vomitting, anorexia, GE reflux SE- nauses, vomitting, anorexia, GE reflux blood levels10-20 mcg/ml
Created by: mashechka
 

 



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