click below
click below
Normal Size Small Size show me how
Acute Inflammation
Question | Answer |
---|---|
Acute Inflammation is characterized by: | Edema and Neutrophils |
2 Stimuli for acute inflammation | Infection and Tissue Necrosis |
Factors of Acute Inflammation | TLR Arachidonic Acids Mast cells Complement Hageman Factor |
CD14 is a TLR that recognizes which PAMP? | LPS, which is on all gram neg. bacteria |
TLR activates up-regulation of ___ | NF-KB |
2 enzymes that act on Arachidonic Acid | Cyclooxygenase and 5-lipooxygenase |
What are the products of Cyclooxygenase and its functions? | Prostaglandins PGI2, PGD2, PGE2 = vasodilation and increase vascular permeability PGE2 = fever and pain |
What are the products of 5-lipooxygenase and its functions? | Leukotrienes LTB4 = attract and activate Neutrophils LTC4, LTD4, LTE4 = vasoconstriction, bronchospasm, increase vascular permeability |
3 factors that activate Mast Cells are? | Tisse trauma Complements (C3a + C5a) IgE binding to antigen |
What are Hageman Factors? | Inactive proinflammatory proteins that are produced in the liver. Activated when they are exposed to tissue collagen |
What is a possible consequence of activated Hageman Factor? | DIC from coagulation and fibrinolytic system |
What are the cardinal signs of acute inflammation? | Rubor, Calor, Tumor, Dolor, Fever |
What causes fever in the inflammation? | Macrophage releases IL1 and TNF -> COX activity is increased -> More PGE2 is released -> Fever |