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Dental pharm 4
Question | Answer |
---|---|
Group 1 penicillins | (cidal) aerobic gram + |
Pen G | parenteral, mixed w/ procaine (penicillins) |
Pen V | oral (penicillin) |
Pen VK | salt, used for dental infections, 500mg qid, 3 day after symptoms gone (penicillin) |
Aminopenicillin | wider spectrum, include gram - |
amoxicillin | tid, well absorbed not affected by food, upper resp. infections (aminopenicillin) |
Augumentin | amoxicillin mixed w/ clavulanic acid (anti-beta lactamase) to increase action (aminopenicillin) |
ampicillin | aminopenicillin |
penicillinase resistant penicillins | used for staph infections, not used in dentistry |
cloxacillin | penicillinase resistant penicillins |
dicloxacillin | penicillinase resistant penicillins |
extended spectrum | used medically for systemic gram (-) infections and in combo with other agents |
carbenicillin | extended spectrum |
ticarcillin | extended spectrum |
erythromycin | E-mycin-static, gram (+) and (-) aerobes, binds reversibly with RNA; inactivated by food & cause upset gastric unless coated; stearate, athylsuccinate, estolate; 1-2g/day 250-500 mg q6h, 1 hac or 2 hpc (MACROLIDE) |
clarithromycin | Biaxin-against some anaerobes, static, work same with protein synthesis, can take w/ food- dose:250-500mg bid (MACROLIDE) |
azithromycin | Zithromax, Z-pak-against some anaerobes, static, work same with protein synthesis, can take w/ food- dose:500mg 1st day, 250mg days 2-5(MACROLIDE) |
tetracycline | broad spectrum, stactic, inhibit RNA protein synthesis; MRSA & helicobacter pylori; side effects: GI upset, P.colitis, candidiasis, liver/kidney toxicity, superinfect.(C.albicans) photosensitivity, stain enamel and dentin |
how is tetracycline used for gingivostomatitis or apthous stomatitis? | mixed w/ lidocaine as a rinse |
clindomycin | Cleocin (Lincosamide)-static, interferes w/protein synthesis, anaerobes linked to serious dental infections, "last resort" (osteomyelitis); side effects:colitis (c.dif), superinfection (c.albicans), skin rashes |
metronidazole | Flagyl-cidal,protozoans and many anaerobes, prodrug activated thru reduction by organisms that unwind DNA; bad interaction w/ alcohol |
cephalosporins | cidal, structurally similar to penicillin and inhibit cell wall synthesis, effective against penicillinase; dental use in special situation, immunocompromised, some prophylaxis |
1st generation cephalosporin | cephalexin (Keflex) |
2nd generation cephalosporin | cephaclor (Ceclor) |
3rd generation cephalosporin | ceftazidime (Fortaz) |
4th generation cephalosporin | cefepime-maxipime |
cephalexin | Keflex |
cephaclor | Ceclor |
ceftazidime | Fortaz |
cefepime | Maxipime |