Increased bp -> increased diuresis and natriuresis -> Decreased BV
What is pressure diuresis/natriuresis?
A few mm hg increase -> doubles the effect of renal output.
What is the two primary determinants of the long-term arterial pressure level?
Shifting the equilibrium point. That is to change the intake/outtake level in ren.
Decribe the arterial pressure in kidney.
CO and peripheral resistant changes while arterial pressure in ren is constant.
Define hyper tension.
Blood pressure s>135 d>90
Hypertension causes?
1) heart failure and coronary heart disease 2)increased bp-> cerbral infarkt (stroke) 3) increased bp-> hemorrage in ren
Hypertension is caused by?
Excessive accumulation of extracellular fluid in the body.
Describe changes in circulary function during volume-loading hypertension!
1) increased extracellular fluid volume-> increased blood volume -> increased CO -> increased bp actives baroreceptors-> Vasodilatation -> decreased resistance
Why does kidney failure cause high pressure?
Kidney can't secrete salt -> hypertension
Salt causes?
1) Stimulation of thirst center in medulla.
What is the salts effect on renin-angiotensin system?
Increased salt intake->Increased ECV-> Increased BP-> Decreased renin & angiotensin-> decreased retention of salt and water-> Return of ECV back to normal-> normal BP
Why does aldesteronism lead to hypertension?
Tumor or patological disorder in adrenal gland -> increase alderone release-> increased salt&water absorbtion ->hypertension
Describe the renin-angiotensin system!
dec. bp->prerenin (stored in juxta glomeruler cells) ->renin (func. enzym) -> angiotensin-I (have a little vasoconstrion effect)-> angiotensin-II (lungs)
What does angiotensin-II (prod. lungs) have for effect?
1)Vasoconstricter (arteriols and little on veins) 2)retention of water & salt (because of renvasoconstrion and better absorbtion) 3) release of aldorone (causes better absorbtion in ren)
mr. charles11
