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hypertension ; )

drugs used for the treatment of hypertension

typemechanism of actiondrugs examplesside effectsspecial notes
ACE Inhibitors block the conversion of angiotensin 1 into angiotensin 2 Lisinopril-Prinivil, Zestril Captopril Enalapril-Vasotec Ramipril-Altace Fosinopril Benazepril cough no ace for pregnant women-can cause serious injury or deatht o the fetus
Angiotensin 2 Receptor Antogonist block the angiotensin at it's receptors Losartan Valsartan no A2RB for pregnant women-can cause serious injury or deatht o the fetus
Calcium Channel Blockers -blocks the flow of calcium into vascular smooth muscle-decreases the force of the heartbeat by decreasing the electrical impulses on th heart muscle Verapmil-Veralan Diltiazem-Cardizem, Dilacor, Tiazac Nifedipine Amlodipine Isradipine calcuim channel blockers vary in their ability to one or the other moa as their primary moaEX. verapamil-affinity for heart and nifedipine-great effect on the periphery
Alpha Adrenergic Blockers blocks alpha receptors at the vascular smooth muscle that signal for vasocontstriction. Prazosin Terazosin Doxazosin first dose synscope is problen with Prazosin.-the resulting decrease in blood pressure is so great the patient may faint. it should be taken at bedtime in bed while laying down. By morning the body will have adjusted new evidence-alpha blockers less effective tahn diuretics alone for preventing heart failure and stroke. patients on doxazosin are twice as likely to be hospitalized for hear failure than those on diuretics alone
"Central Acting" HTN drugs acts directly on the blood vessels to produce dilation, decreases 'message generation" from the brain to constrict blood vessels Methyldopa Clonidine-Catapress clonidine cautions-causes bad rebound HTN when stopped abruptly. Always taper off when stopping clonidine. Clonidine is the only HTN drug avaialable in topical patch form
Diuretics: Thiazide decrease re-apsorption of sodium and potassium thus causing more fluid to be eliminated via the kidneys HCTZ-microzide Indapomide Metolazone-Zaroxolyn Chrolthalidone-Hygroton potassium delpletion from the body, K+ monitoring and possible supplementatiion may be needed exert their effects on the kidney's filtration system-work in the distal tube
Diuretics:Loop decrease re-apsorption of sodium and potassium thus causing more fluid to be eliminated via the kidneys Furosemide-Lasix Bumetanide-Bumex Ethacrynic Acid potassium delpletion from the body, K+ monitoring and possible supplementatiion may be neededototoxicity at high doses(tinnitis, loss of hearing) exert their effects in the kidney's filtration system-work in the loop of henle
Beta Blockers blockade of beta receptors at the heart. they decrease the heart rate and the force of the heart, by blocking the message the body sends to the heart Atenolol-Tenormin -Lopressor, Toprol Bisoprodol sotalol-Betapace no beta blockers fo asthmatics or diabetics(blocks the signs of hypoglycemia)
Created by: kizzy on 2009-06-04



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