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Cytokine Matching
Cytokines in Immunology Matching
Cytokine | Source | Main target + effect |
---|---|---|
IL-2 | Th1 cells | Th1: increase IL-2 high affinity receptors, increase IL-2 production, upregulate adaptive immune system |
IL-3 | Activated T helper cells | Hematopoietic stem cell differentiation |
IL-4 | Th2 cells, Treg cells | B cell differentiation + class switch to IgE |
IL-5 | Th2 cells | B cell differentiation + class switch to IgA |
IL-6 | Th2 cells, APCs | B cell conversion to plasma cells; plasma cell secretion of antibody; hepatocyte secretion of acute phase reactants |
IL-8 (CXCL8) | Macrophages | Neutrophil chemotaxis |
IL-10 | Th2 + Treg cells | Activates Th2, Inhibits Th1 |
IL-12 | APCs | Induces CD4+ cell differentiation into Th1 cells; activates Th1 cells; activates NK cells |
IL-13 | Th2, Mast cells, NK cells | Activate macrophages; stimulate IgE production |
IFN-gamma | Th1 cells, NK cells | Activate macrophages, B cells, NK cells; Inhibit Th2 cells; suppress viral replication |
TNF-alpha | APCs, Th1 cells | Increases IL-2 receptor synthesis in TH1 cells; increases B cell proliferation; neutrophil chemotaxis; systemic + local inflammatory mediator |
GM-CSF | Th1 + Th2 cells | Leukocyte differentiation from myeloid progenitor cells |
IL-1 | APCs | Inflammatory + Pyrogenic |