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GHY2
Hi Yield goljan pt2
Question | Answer |
---|---|
Brain atrophy | ischemia; Alzheimer’s |
Exocrine gland atrophy in CF | duct obstruction by thick secretions |
Labile cells | stem cells (skin, marrow, GI tract) →←→⇦ |
Stable cells | in G0 phase (smooth muscle, hepatocytes); can enter cell cycle (growth factors, hormones) |
Permanent cells | cannot replicate; cardiac/striated muscle; neurons |
Hypertrophy | increase in cell size (structural components, DNA) |
LVH | increased preload (valve regurgitation), increased afterload (hypertension, aortic stenosis) |
RVH | pulmonary hypertension |
Bladder smooth muscle hypertrophy | prostate hyperplasia constricts urethra |
Removal of kidney | hypertrophy of remaining kidney |
Hyperplasia | increase in number of cells |
Endometrial hyperplasia | unopposed estrogen (obesity, taking estrogen) |
RBC hyperplasia | increased EPO (blood loss, ectopic secretion, high altitude) |
Prostate hyperplasia | increased dihydrotestosterone (DHEA) |
Gynecomastia | hyperplasia male breast tissue; normal in newborn, adolescent, elderly |
Metaplasia | one adult cell type replaces another cell type |
Squamous metaplasia in bronchus | smoking |
Intestinal metaplasia in stomach | Paneth cells, goblet cells; H pylori chronic atrophic gastritis |
Squamous metaplasia bladder | Schistosoma hematobium infection |
Barrett’s esophagus | glandular metaplasia of distal esophagus; due to GERD |
Dysplasia | atypical hyperplasia and metaplasia are precursors for cancer |
Squamous dysplasia in cervix | human papilloma virus |
Squamous dysplasia in bronchus | smoking |
Necrosis | death of groups of cells |
Coagulation necrosis | preservation of structural outline (due to ↑ lactic acid) |
Infarction | pale (e |
Liquefactive necrosis | brain infarct, bacterial infections; wet gangrene |
Caseous necrosis | variant coagulation necrosis; granulomas due to TB/systemic fungi |
Granulomas | activated macrophages (epithelioid cells); multinucleated giant cells; CD4 TH1 cells |
Epithelioid cells | γ-interferon released by CD4 T cells activates macrophages |
Multinucleated giant cells | fusion of epithelioid cells |
Granulomas | type IV hypersensitivity |
Enzymatic fat necrosis | associated with pancreatitis; soap formation (Ca2+ + fatty acids) |
Fibrinoid necrosis | necrosis of immune reactions (immune vasculitis/endocarditis) |
Postmortem necrosis | autolysis; no inflammatory reaction |
Dystrophic calcification | calcification of damaged tissue; normal serum calcium |
Dystrophic calcification | pancreatitis; atherosclerotic plaque |
Metastatic calcification | calcification of normal tissue; increased serum calcium or phosphorus |
Nephrocalcinosis | metastatic calcification of collecting tubule basement membranes |
S/S nephrocalcinosis | polyuria due to nephrogenic diabetes insipidus; renal failure |
Apoptosis | gene regulated individual cell death |
Signals activating apoptosis | mullerian inhibitory factor, tumor necrosis factor, hormone withdrawal |
Signal modulators of apoptosis | TP53 suppressor gene, BCL-2 genes |
BCL-2 genes | anti-apoptosis gene; prevents cytochrome c from leaving mitochondria |
Caspases | responsible for enzymatic cell death in apoptosis; proteases and endonucleases |
Markers of apoptosis | eosinophilic cytoplasm, pyknotic (ink dot) nucleus |
Apoptosis | loss Mullerian epithelium in male fetus; thymus involution; killing cancer cells |
Histamine | key chemical in acute inflammation; mast cell; arteriole vasodilation; ↑ venular permeability |
Rubor acute inflammation | redness; arteriole vasodilation (histamine) |
Calor acute inflammation | heat; arteriole vasodilation (histamine) |