Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

NSAIDs lecture

NSAIDs lecture notes

QuestionAnswer
What is the mechanism of action of Aspirin? It irreversity inhibits COX1 and COX2, thereby inhibiting PGI2(prostacyclin), PGE2(prostaglandins) and TXA2(THromboxane)
What is the clinical use of aspirin in low doses? <300mg/day: dereases platelet aggregation
What is the clinical use of aspirin in intermediate doses? 300-2400mg/day:antipyretic and analgesic
What is the clincial use of aspirin in high dosage? anti-inflammatory
What are some of the side effects of aspirin? Gastric upset, chronic use can lead to renal failure, interstitial nephritis and upper GI bleeding, Reyes syndrome.
What does PGI2(prostacyclin) do? decreases platelet aggregation, vasodilation, decreases uterine tone
What does PGE2(prostaglandins) do? decreases vascular tone, increases pain, uterine tone, and temperature
What does TXA2(Thromboxane) do? Increases platelet aggregation and causes vasoconstriction
Name some of the traditional NSAIDs? Ibuprofen, naproxen, indomethacin, ketorolac, diclofenac
What are the clinical uses of NSAIDs? Antipyretic, analgesic, anti-inflammatory. Indomethacin is used to close a PDA.
What are the side effects of NSAIDs? AntRenal damage, GI distress, ulcers, aplastic anemia
What is the name of the COX-2 inhibitor? celecoxib
Is celecoxib better than aspirin in it's antiplatelet effect? No
What is the MOA of celecoxib? Inhibits COX-2 which is found on in inflammatory cells/vascular endothelium. Spares COX-1 which maintains the gastric mucosa - thus doesn't have the corrosive effects of other NSAIDS on the GI.
What is the usage of celecoxib? RA and OA
What are the side effects of celecoxib? increases risk of thrombosis, sulfa allergy, less toxicity to GI muosa
Created by: villagejoker
Popular Medical sets
Geneeskunde M1
Heelkunde M1
M1 beweging Groningen
Toetsvragen
Beweging
Medical roots
NHA CBCS Exam
Doug Best's Medical Terminology On-Line Class - 2/09
toetsvragen opleiding Groningen
Medical Terminology: Root Words
Combining Form, Suffix, Prefix & Meaning
Medical Terminology

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards