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NSAIDs & Gout

Todorov; Nonsteroidal anti-inflammatory drugs & Gout

QuestionAnswer
What drug category is Aspirin in? Nonselective Cyclooxygenase (COX) Inhibitors
What drug is a Nonselective Cyclooxygenase (COX) Inhibitors? Aspirin, Acetaminophen (Tylenol), Ibuprofen (Advil)
What Drug Category is Acetaminophen (Tylenol) in? Nonselective Cyclooxygenase (COX) Inhibitors
What drug category is Ibuprofen (Advil) in? Nonselective Cyclooxygenase (COX) Inhibitor
What drug is a Selective Cyclooxygenase-2 (COX-2) Inhibitor? Celecoxib (celebrex)
What drug category is Celeoxib (Celebrex) in? Selective Cyclooxygenase-2 (COX-2) Inhibitors
What are disease-modifying antirheumatic drugs? -Gold Salts (Gold Sodium Thiomalate) -Glucocorticoids (Prednisone) -Others (Methotrexate
What drugs PREVENT gout? Probenecid (Benemid) -Allopurinol (Zyloprim)
What drugs TREAT gout? Colchicine
What is rheumatoid arthritis? An autoimmune disorder of unknown etiology.
What are characteristics of rheumatoid arthritis? systemmic joint inflammation and progressive joint destruction, deformity, disability, and premature death. Cardiopulmonary, neurological, and ocular inflammantion.
What is Osteoarthritis? A degenerative disease of the large, weight-bearing joints.
What are the characteristics of osteoarthritis? Inflammation, thinning, and destruction of the cartridge layer of the joint. Leading to bone erosions associated with stiffness, pain, and muscle weakness. The cartilage undergoes thickening,inflammation,splittign,& thinning.
What is Gout? Gout is an arthritic syndrome caused inflammatory response to crystals of monosodium urate monohydrate in joints, renal tubules, & other. The deposition of these crystals occur as a consequence of hyperuricemia,can result from overproduction uric acid
What are some characteristics of Gout? Painful joint inflammation due to mechanical irritation by the urate crystals.
Prostaglandins what are they responsible for? Roles in inflammation,fever,pain. Pain:sensitize sensory nerves and amplify pain sensation. Inflammation:promote inflamation(vasodilation) -Fever:Elevate body temp.
How do NSAIDs alleviate fevers? By inhibiting the prostaglandin synthesis in the hypothalamus but they do not reduce the body temperature below normal.
What is NSAIDs mechanism of action? *Decrease Production of PROSTAGLNDINS -Inhibit cyclooxygenase (COX), an enzymes that catalyzes the first step in the synthesis of prostaglandins from arachidonic acid and other precursor fatty acids.
What is prostaglandins effect? Prostaglandins are released from cells in response to chemical stimuli or trauma.
What are NSAIDs effective for? NSAIDs are effective in relieving pain caused by tissue inflammation or by bone or joint trauma, and they can be combined with opiod to obtain a better analgesic effect an reduce need for higher doses of opiods.
Created by: allievisner2
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