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2nd Top 200
| Brand | Generic | Schedule | MOA | Indications | C/I | ADRs | BBW |
|---|---|---|---|---|---|---|---|
| Tylenol/Codeine | acetaminophen/codeine | C-III (tablet) C-V (liquid) | Opioid Analgesic Combination | Pain management | -Acute/severe bronchial asthma -Postoperative pain management in children after tonsillectomy/adenoidectomy -Significant respiratory depression | None | Med errors; Addiction, abuse, & misuse; Life-threatening resp depression; Accidental ingestion; Neonatal opioid w/drawal syndrome; Hepatotoxicity; Death related to rapid metabolism of codeine-morphine; 3A4 interactions; Use w/ benzos/other CNS depressants |
| Humira | adalimumab | Rx | DMARD; TNF Blocking Agent | Ankylosing spondylitis Ulcerative colitis Crohn disease Hidradenitis suppurativa Plaque psoriasis Uveitis Psoriatic arthritis RA | None | -HA -Skin rash -Positive ANA titer -AB development -Injection site reaction -URI, sinusitis -Increased creatine phosphokinase | Serious infections; Malignancy |
| Zyloprim | allopurinol | Rx | Antigout Agent; Xanthine Oxidase Inhibitor | Gout Cancer therapy-induced hyperuricemia Calcium oxalate stones (recurrent) | None | -Skin rash -Gout, acute -Nausea, diarrhea | None |
| Xanax | alprazolam | C-IV | Benzodiazepine | Anxiety disorders Panic disorder | -Acute narrow-angle glaucoma -Concurrent use with ketoconazole, itraconazole, or other potent CYP3A4 inhibitors | -Drowsiness, fatigue, sedation, ataxia, memory impairment, irritability, cognitive dysfunction, dysarthria, DZ, depression -Skin rash -Weight gain/loss, decreased libido -Inc/dec appetite, constipation, xerostomia -Difficulty in micturition | Use w/opioids |
| Elavil | amitriptyline | Rx | TCA; Increases the synaptic concentration of serotonin and/or NE in CNS by inhibition of their reuptake by the presynaptic neuronal membrane pump | Depression | -W/in 14 days of MAOIs -Cisapride -Acute recovery phase following MI | None | Suicidality & antidepressant drugs |
| Adderall, Adderall XR | amphetamine salts (XR) | C-II | CNS Stimulant | ADHD Narcolepsy | -Advanced arteriosclerosis -Symptomatic CV disease -Moderate-severe HTN -Hyperthyroidism -Glaucoma -Agitated states -Hx of drug abuse -W/in 14 days of MAOI | -Systolic HTN -Insomnia, HA -Weight loss -Decreased appetite, xerostomia, abd pain | Abuse potential; CV events |
| Abilify | aripiprazole | Rx | SGA; Partial agonist at D2 & 5-HT1A receptors, & as an antagonist at 5-HT2A receptor | Acute agitation (schizophrenia/bipolar mania) Bipolar I disorder (acute manic/mixed episodes) Depression (adjunctive w/antidepressants) Schizophrenia | None | -HA, extrapyramidal, drowsiness, akathisia, fatigue, sedation, agitation, insomnia, anxiety -Weight gain, increased serum cholesterol/TGs/Glu, decreased HDL, Increased LDL -N/V/C -Tremor | Increased mortality in elderly pts w/dementia-related psychosis; Suicidality & antidepressant drugs |
| Strattera | atomoxetine | Rx | Selective NE Reuptake Inhibitor | ADHD | -W/in 14 days of MAOIs -Narrow-angle glaucoma -Pheochromocytoma -Severe CV disorders | -HA, insomnia, drowsiness -Hyperhidrosis -Xerostomia, nausea, decreased appetite, abd pain, vomiting, constipation -Erectile dysfunction | Suicide ideation in children & adolescents |
| Gablofen, Lioresal | baclofen | Rx | Skeletal Muscle Relaxant | Spasticity | -Intrathecal: IV, IM, SQ, or epidural admin. | -Hypotonia, drowsiness, confusion, HA -N/V | Abrupt withdrawal (injection) |
| Cogentin | benztropine | Rx | Possesses both anticholinergic & antihistaminic effects | Drug-induced extrapyramidal symptoms -Acute dystonic reactions Parkinsonism, idiopathic -Postencephalitic | -< 3 y/o | None | None |
| Suboxone, Bunavail, Zubsolv | buprenorphine/naloxone | C-III | Buprenorphine: high affinity binding to mu opiate receptors in the CNS; displays partial mu agonist & weak kappa antagonist activity Naloxone: pure opioid antagonist that competes and displaces opioids at opioid receptor sites | Opioid Dependence | None | -HA, withdrawal syndrome, pain -Diaphoresis -Glossodynia (film), oral hypoesthesia (film), oral mucosa erythema (film) | None |
| Fiorcet, Esgic | butalbital/APAP/caffeine | Rx | Butalbital: barbiturate Acetaminophen: inhibits the synthesis of prostaglandins in CNS & peripherally blocks pain impulse generation Caffeine: CNS stimulant | Tension/muscle contraction HA | -Porphyria | None | Hepatotoxicity |
| Soma | carisoprodol | C-IV | Skeletal Muscle Relaxant | Acute musculoskeletal pain, short-term (2-3 wks) | -Hypersensitivity to carbamates -Hx of acute intermittent porphyria | -Drowsiness | None |
| Celebrex | celecoxib | Rx | NSAID, COX-2 Selective | Acute pain Primary dysmenorrhea Ankylosing spondylitis OA RA Juvenile Idiopathic Arthritis | -Hypersensitivity to sulfonamides, ASA, other NSAIDs -Experienced asthma, urticarial, or allergic-type rxns after taking ASA or other NSAIDs -use in CABG surgery | None | Serious CV risk; Serious GI risk |
| Celexa | citalopram | Rx | SSRI | Depression | -W/in 14 days of MAOIs -Linezolid or IV methylene blue -Pimozide | -Drowsiness, insomnia -Diaphoresis -Nausea, xerostomia | Suicidality & antidepressants |
| Klonopin | clonazepam | C-IV | Benzodiazepine | Panic disorder Seizure disorder | -Hypersensitivity to other benzos -Significant liver disease -Acute narrow-angle glaucoma | Drowsiness, ataxia, behavioral problems, DZ | Use w/opioids |
| Plavix | clopidogrel | Rx | Antiplatelet Agent; Prodrug irreversibly blocks the P2Y12 component of ADP receptors of plt surface (prevents activation of GPIIb/IIIa receptor complex=↓ plt aggregation) | ACS (UA, NSTEMI, STEMI) Recent MI, stroke, or PAD | -Active pathological bleeding (peptic ulcer, intracranial hemorrhage) | None | Diminished antiplatelet effect in pts w/ 2 loss-of-function alleles in CYP2C19 gene |
| Colcrys | colchicine | Rx | Antigout Agent; Disrupts cytoskeletal functions by inhibiting beta-tubulin polymerization into microtubules, preventing activation, degranulation & migration of neutrophils associated w/mediating some gout symptoms | Familial Mediterranean fever (FMF) Gout: -Flare -Px | -Use of P-gp or strong CYP3A4 inhibitor w/ renal/hepatic impairment | -GI disease, diarrhea, vomiting, nausea | None |
| Flexeril, Amrix | cyclobenzaprine | Rx | Centrally-acting skeletal muscle relaxant pharmacologically related to TCAs; reduces tonic somatic motor activity influencing both alpha and gamma motor neurons | Muscle spasm | -W/in 14 days of MAOI -Hyperthyroidism -HF, arrhythmias, heart block or conduction disturbances -Acute recovery phase of MI | -Drowsiness, DZ -Xerostomia | None |
| Pristiq | desvenlafaxine | Rx | SNRI | Depression | -W/in 14 days of MAOI -Linezolid, IV methylene blue | -DZ, insomnia -Hyperhidrosis -Nausea, xerostomia | Suicidal thoughts & behavior |
| Focalin XR | dexmethylphenidate | C-II | CNS Stimulant; More active form of methylphenidate; blocks reuptake of NE & DA, & increases their release into the extraneuronal space | ADHD | -Marked anxiety, tension, agitation -Glaucoma -Motor tics, Tourette syndrome -W/in 14 days of MAOI | -HA, insomnia, restlessness, anxiety -Decreased appetite, xerostomia, abd pain | Drug dependence |
| Valium | diazepam | C-IV | Benzodiazepine; Binds to stereospecific benzo receptors on postsynaptic GABA neuron at several sites w/in CNS leading to increased permeability to Cl- and hyperpolarization | Acute EtOH withdrawal Anxiety Muscle spasm Preoperative anxiety Seizures Status epilepticus Skeletal muscle relaxant (adjunct) | -Acute narrow-angle glaucoma, untreated open-angle glaucoma -< 6M (oral) -Myasthenia gravis -Severe respiratory impairment -Severe hepatic impairment -Sleep apnea syndrome (oral tab) | None | None |
| Voltaren Gel | diclofenac | Rx | NSAID, topical | OA | -Hx of asthma, urticarial, or other allergic-type rxns after taking ASA or other NSAIDs -Use in CABG surgery | -Pruritus, application site rash, contact dermatitis, xeroderma, application site pain, desquamation -Increased serum transaminases | Serious CV thrombotic events; Serious GI bleeding, ulceration, & perforation |
| Depakote | divalproex | Rx | Increases availability of GABA to brain neurons or may enhance action of GABA or mimic its action at postsynaptic receptor sites | Seizures Mania Migraine Px | -Hepatic disease -Urea cycle disorders -Pregnant women for migraine Px -Mitochondrial disorders | -HA, drowsiness, DZ, insomnia, nervousness -Alopecia -N/V/D, dyspepsia, abd pain, anorexia -Thrombocytopenia, infection -Tremor, weakness -Diplopia, visual disturbances -Flu-like symptoms | Hepatotoxicity; Pt w/mitochondrial disease; Fetal risk; Pancreatitis |
| Lexapro | escitalopram | Rx | SSRI | MDD GAD | -W/in 14 days of MAOI -Linezolid, IV methylene blue -Pimozide | -HA, insomnia, drowsiness -Nausea, diarrhea -Ejaculatory disorder | Suicidality & antidepressant drugs |
| Lunesta | eszopiclone | C-IV | Hypnotic; May interact w/GABA-receptor complexes at binding domains located close to or allosterically coupled to benzo receptors | Insomnia | None | -HA -Dysgeusia | None |
| Enbrel | etanercept | Rx | DMARD; TNF Blocking Agent | Ankylosing spondylitis Psoriatic arthritis RA Plaque psoriasis Polyarticular juvenile idiopathic arthritis | -Sepsis | -HA -Skin rash -Abd pain, diarrhea, vomiting -Infection -Injection site rxn -RTI, rhinitis -Ab development, positive ANA titer | Serious infections; Malignancies |
| Duragesic | fentanyl transderm | C-II | Increases pain threshold, alters pain reception, inhibits ascending pain pathway in CNS | Chronic pain | -Severe respiratory disease, acute asthma -Paralytic ileus -Acute/intermittent pain, short-term therapy, postoperative/mild pain -Pts NOT opioid tolerant | -Confusion, DZ, drowsiness, fatigue, HA, sedation -Dehydration -N/V/C -Weakness -Dyspnea | Addiction, abuse, & misuse; Life-threatening resp depression; Accidental exposure; Neonatal opioid w/drawal syndrome; CYP3A4 interaction; Exposure to heat |
| Prozac, Sarafem | fluoxetine | Rx | SSRI | MDD OCD Bulimia nervosa Panic disorder PMDD | -W/in 14 days of MAOI -Linezolid, IV methylene blue -Pimozide, thioridazine | -Insomnia, HA, drowsiness, anxiety, nervousness, yawning -Decreased libido -Nausea, diarrhea, anorexia, xerostomia -Weakness, tremor -Pharyngitis | Suicidality & antidepressant drugs |
| Folic acid | folic acid | Rx | Necessary for formation of purine & pyrimidine synthesis, required for nucleoprotein synthesis & maintenance in erythropoiesis, stimulates WBC & plt production in folate deficiency anemia | Megaloblastic & macrocytic anemias | None | None | None |
| Hycet, Lorcet, Lortab, Norco, Verdrocet, Vicodin, Zamicet | hydrocodone/APAP | C-II | Opioid Analgesic Combination | Pain management | -CNS depression -Severe respiratory depression | None | Hepatotoxicity |
| Lamictal | lamotrigine | Rx | Triazine derivative which inhibits release of glutamate (excitatory) & inhibits voltage-sensitive Na+ channels, which stabilizes neuronal membranes | Bipolar I disorder (IR only) Epilepsy | None | -Nausea | Serious skin rashes |
| Xalatan | latanoprost | Rx | Prostaglandin F2-alpha analog; increase outflow of aqueous humor | Elevated IOP | None | -Foreign body sensation of eye -Epithelial keratopathy | None |
| Vyvanse | lisdexamfetamine dimesylate | C-II | CNS Stimulant; Prodrug for dextroamphetamine, a sympathomimetic amine that causes release of DA & NE from storage site in presynaptic nerve terminals | ADHD Binge eating disorder | -W/in 14 days of MAOI | -Insomnia -Decreased appetite, xerostomia, upper abd pain | Abuse & dependence |
| Ativan | lorazepam | C-IV | Benzodiazepine; Binds to stereospecific benzo receptors on postsynaptic GABA neuron at several sites w/in CNS leading to increased permeability to Cl- and hyperpolarization | Anxiety disorder Insomnia due to anxiety/stress Premedication for anesthesia Status epilepticus | -Hypersensitivity to other benzos -Acute narrow-angle glaucoma -Sleep apnea (parenteral) -Intra-arterial injection of parenteral formulation -Severe respiratory insufficiency | None | None |
| Rheumatrex | methotrexate | Rx | DMARD; Antimetabolite (Antifolate) | Acute lymphoblastic leukemia (ALL) Breast cancer Choriocarcinoma Chorioadenoma Gestational trophoblastic diseases Head & neck cancer Lymphoma, non-Hodgkin Mycosis fungoides Osteosarcoma Psoriasis RA | -Breast-feeding For psoriasis or RA: -Pregnancy -Alcoholism -Alcoholic liver disease, chronic liver disease -Immunodeficiency syndromes -Blood dyscrasias | None | IT & high-dose therapy; Appropriate use; Pregnancy; Bone marrow suppression; Renal impairment; Hepatotox; Pneumonitis; GI toxici; 2° malignancy; Tumor lysis syndrome; Dermatologic tox; Opportunistic infections; Radiotherapy; Experienced physician (inj) |
| Medrol | methylprednisolone | Rx | Corticosteroid, Systemic | Allergic conditions Anti-inflammatory or immunosuppressive Asthma -exacerbations -maintenance MS, acute exacerbation | -Systemic fungal infection -IT administration -Live/attenuated virus vaccines -Use in premature infants | None | None |
| Nasonex, Asmanex | mometasone | Rx | Corticosteroid | Oral: Asthma Nasal: Allergic rhinitis, Nasal congestion associated w/seasonal rhinitis, Nasal polyps, Px seasonal allergic rhinitis | -Hypersensitivity to milk proteins (Twisthaler only) -Primary Tx of status asthmaticus or other acute episodes of asthma for which intensive measures are required | -HA, fatigue, depression -Oral candidiasis -Pain, arthralgia -Sinusitis, allergic rhinitis, URTI, pharyngitis, cough, epistaxis -Viral infection | None |
| Singulair | montelukast | Rx | Leukotriene Receptor Antagonist | Allergic rhinitis (perennial or seasonal) Asthma Exercise-induced Bronchoconstriction | None | -HA | None |
| Dilantin | phenytoin | Rx | Stabilizes neuronal membranes & decreases seizure activity by increasing efflux or decreasing influx of Na+ across cell membranes in motor cortex during generation of nerve impulses | Status epilepticus Anticonvulsant | -Hypersensitivity to other hydantoins -Delvirdine -IV only: Sinus bradycardia, sinoatrial block, second- & third-degree heart block, Adams-Stokes syndrome | None | CV risk associated w/rapid infusion (injection) |
| Pravachol | pravastatin | Rx | HMG-CoA Reductase Inhibitor | Hyperlipidemia Primary Px of coronary events Secondary Px of CV events | -Active liver disease, unexplained persistent elevations of serum transaminases -Pregnancy, breast-feeding | None | None |
| Lyrica | pregabalin | C-V | Inhibit excitatory NT release by modulating Ca2+ influx at voltage gated Ca2+ channels in CNS nerve terminals | Fibromyalgia Neuropathic pain Partial-onset seizures Postherpetic neuralgia | None | -Peripheral edema -DZ, somnolence, ataxia, HA, fatigue -Weight gain -Xerostomia -Infection -Tremor -Blurred vision, diplopia -Accidental injury | None |
| Inderal | propranolol | Rx | Beta-Blocker, nonselective | Essential tremor HTN Migraine Px Obstructive hypertrophic cardiomyopathy Pheochromocytoma Post-MI mortality reduction Stable angina Tachyarrhythmias | -Hypersensitivity to beta-blockers -Uncompensated CHF, cardiogenic shock, severe sinus bradycardia, sick sinus syndrome, or heart block (>1st-degree) -Bronchial asthma | None | Cardiac ischemia after abrupt discontinuation (Inderal LA & XL) |
| Crestor | rosuvastatin | Rx | HMG-CoA Reductase Inhibitor | Familial hypercholesterolemia Hyperlipidemia & mixed dyslipidemia Hypertriglyceridemia Primary dysbetalipoproteinemia Px of CV disease | -Active liver disease, unexplained persistent elevations of serum transaminases -Pregnancy, breast-feeding | -Myalgia | None |
| Zocor | simvastatin | Rx | HMG-CoA Reductase Inhibitor | Hyperlipidemia Secondary Px of CV disease | -Active liver disease, unexplained persistent elevations of serum transaminases -Strong CYP3A4 inhibitors -Cyclosporine, danazol, gemfibrozil -Pregnancy, breast-feeding | None | None |
| Vytorin | simvastatin/ezetimibe | Rx | HMG-CoA Reductase Inhibitor & Inhibits absorption of cholesterol at brush border of small intestine (via NPC1L1) | Homozygous familial hypercholesterolemia Primary hyperlipidemia Primary & secondary Px of CV disease | -Active liver disease, unexplained persistent elevations of serum transaminases -Strong CYP3A4 inhibitors -Cyclosporine, danazol, gemfibrozil -Pregnancy, breast-feeding | None | None |
| Timoptic, Timoptic XE | timolol (XE) | Rx | Beta-Blocker, nonselective | Elevated IOP | -Bronchial asthma (or Hx), Severe COPD -Sinus bradycardia, 2nd- or 3rd-degree AV block, Overt cardiac failure, Cardiogenic shock | -Burning sensation of eyes, stinging of eyes | None |
| Travatan Z | travoprost | Rx | Selective FP prostanoid receptor agonist; Increase trabecular meshwork & outflow | Elevated IOP | None | -Ocular hyperemia | None |
| Dyazide, Maxzide | triamterene/hydrochlorothiazide | Rx | K+ Sparing Diuretic & Thiazide Diuretic | HTN Edema | -Hypersensitivity to sulfonamides -Anuria, acute & chronic renal insufficiency, significant renal impairment -K+ sparing diuretics, K+ containing salt substitutes, or K+ supplements (except in severe cases of hypokalemia) -Preexisting hyperkalemia | None | Hyperkalemia |
| Depakene | valproic acid | Rx | Increases availability of GABA to brain neurons or may enhance action of GABA or mimic its action at postsynaptic receptor sites | Seizures | -Hepatic disease -Urea cycle disorders -Pregnant women for migraine Px -Mitochondrial disorders | -HA, drowsiness, DZ, insomnia, nervousness -Alopecia -N/V/D, dyspepsia, abd pain, anorexia -Thrombocytopenia, infection -Tremor, weakness -Diplopia, visual disturbances -Flu-like symptoms | Hepatotoxicity; Pts w/mitochondrial disease; Fetal risk; Pancreatitis |
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kcapizzi
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