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Pharm test 1
Question | Answer |
---|---|
botulinum toxin | blocks release of ach from nerve terminal |
alpha-latrotoxin | causes mass release of ach from nerve terminal |
pilocarpine | muscarinic agonist- dry mouth |
bethanechol | muscarinic agonist- post op urine retention |
cevimeline | muscarinic agonist - sjogren's |
atropine | muscarinic antagonist - crosses bbb - antidote for physostigmine and war gases |
scopolamine | muscarinic antagonist - crosses bbb - antiemetic |
physostigmine | ACh E inhibitor - will cross bbb |
edrophonium | ACh E inhibitor - very short acting - diagnose m. g. |
neostigmine | ACh E inhibitor - intermediate acting - reversal for non-depolarizing nmj blocker - treatment for m. g. |
Malathion, parathion, diazinon | Irreversible ACh E inhibitor - insect repellant |
Sarin, soman, tabun | Irreversible ACh E inhibitor - war gases |
2 - pralidoxime | ACh E reactivator - must be used within 12 hours - attractive to the irreversible ACh E inhibitors more than the ACh E enzyme |
Diazepam | Used to prevent convulsant effects from too much ACh in the brain |
respiratory support | needed for too much or too little ACh or nmj blockers or succ |
nicotine | Ganglionic stimulator - full agonist |
veranicline | Ganglionic stimulator - partial N agonist |
tubocurarine | Long duration non-depolarizing nmj blocker |
pancuronium | Intermediate duration non-depolarizing nmj blocker |
mivacurium | Short duration non-depolarizing nmj blocker |
Succinylcholine | Non-competive depolarizing nmj blocker |
Norepinephrine | A1, A2, B1 - will cause increased vasoconstriction more than epinephrine |
Epinephrine | A1, A2, B1, B2 - will cause more dilation and higher HR at lower doses but a bolus will get constriction and decreased HR from reflex |
Dopamine | DA, A1, B1 - will increase urine output at low doses and is good for CHF |
Phenylephrine | A1 agonist |
Ephedrine | A1 agonist, also an indirect adrenergic agonist because it increases NE at synaptic cleft similar to amphetamine and tyramine |
Pseudoephedrine | A1 agonist, also and indirect adrenergic agonist |
Clonidine | A2 central agonist |
Methoxamine | A1 agonist |
Oxymetazoline | A1 and peripheral A2 agonist |
Naphazoline | A1 agonist |
Isoproteronol | B1 and B2 agonist - bradycardia and cardiac arrest |
Dobutamine | B1 agonist - CHF |
Albuterol | B2 agonist - asthma/COPD |
Terbutaline | B2 agonist - asthma/COPD |
Metaproteronol | B2 agonist - asthma/COPD |
Ritodrine | B2 agonist - relaxes uterus |
Phenoxybenzamine | A1 and A2 antagonist - non-competative action - used for pheochromocytoma |
Phentolamine | A1 and A2 antagonist - competative action - used for alpha agonist OD and restore sensation after dental anesthesia |
Prazosin | A1 antagonist - for hypertension and BPH |
Propranolol | B1 and B2 antagonist |
Nadolol | B1 and B2 antagonist |
Timolol | B1 and B2 antagonist |
Pindolol | B1 and B2 antagonist |
Atenolol | B1 antagonist |
Metoprolol | B1 antagonist |
Labetalol | B1, B2, A1 antagonist |
Carvedilol | B1, B2, A1 antagonist |
B1 and B2 non-selective antagonists used to treat... | htn, angina, MI, arrythmia, stage fright, glaucoma, tremor, migraine, anxiety |
B1 selective antagonists used to treat... | Cardioselective so decrease HR but dont affect people with asthma unless the dose is too high then it will have b2 effects |
B1, B2, A1 non-selective antagonists used to treat.. | CHF, they block biased agonists and teach the heart to beat differently |
Tyramine | Indirect adrenergic agonist - rides on reuptake 1 (NET) and gets in terminal and kicks out NE |
Tyramine is in what foods... | wine, cheese, beer, fish |
Amphetamine | Indirect adrenergic agonist - rides reuptake 1 and releases NE, high A1 and A2 so BP up and reflex HR down. High NE fights against reflex brady and can cause arrythmias |
Cocaine | NE uptake inhibitor - by blocking NET back into the cell; Also Na channel blocker and can cause numbness |
Trycyclic antidepressant | NE uptake inhibitor |
Guanethadine | Neuronal blocker - inhibits NE release similar to botox with ACh, problem is if bp goes down the reflex would say to increase sympathetic and release NE but this drug prevents that HR and BP stay down |
Reserpine | Neuronal blocker - inhibits vesicular uptake of NE so it gets eaten up by intraneuronal monoamine oxidase |