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Benign Lesions
Derm
Question | Answer |
---|---|
Seb keratosis found anywhere except | palms & soles |
Seb keratosis variants | dermatosis papulosa nigra (AA pts): on the face; stucco keratosis (older Caucasians): on lower legs, ankles, and dorsal hands / feet |
Sign of Leser-Trelat: | Sudden eruption of many seborrheic keratoses may be a cutaneous sign of internal malignancy |
Achrocordon most common in: | women & obese pts |
Dermatofibroma sites | usually legs, but also trunk & arms |
Dimple sign & button sign: for: | dermatofibroma |
Contents: cheesy consistency and a nasty odor: | epidermal cyst |
organized clusters of melanocyte-derived nevus cells | nevi (moles) |
These have a life cycle of their own: | nevi |
Nevus: 3 types | junctional, compound, intradermal |
Junctional nevus: | clustered at the dermal-epidermal junction (DEJ); Flat or slightly raised, tan or brown, round or oval lesions |
compound nevus: | Nevus cells found at both the DEJ & in the dermis; Slightly to markedly raised, tan, brown, or black papules. |
intradermal nevus: | Raised, soft, flesh-colored, tan, or brown papules. Pigment may be arranged in flecks; may see coarse hairs |
halo nevus | rim of depigmentation; autoimmune; usually repigments; may be assoc w/vitiligo & malignant melanoma |
spitz nevus | kids (rarely adults); benign, pink, tan, or brown dome-shaped smooth papules; face, scalp, neck, and legs; rapid growth; excision bc melanoma may arise from spitz nevus |
developmental anomaly appearing as a brown patch, a patch of hair, or both: | becker’s nevus |
Congenital Melanocytic Nevus: Increased risk of malignant melanoma in: | lesions larger than 20 cm. |
Ephilides = | freckles |
Fordyce spots: | Ectopically located sebaceous glands |
Do not blanch well using diascopy: | cherry angioma |
Spider angioma: diascopy: | Common, benign, dilatation of superficial bleed vessels; Arteriole perpendicular to skin; radiating vessels easily blanch with diascopy, but central vessel may not, and may pulsate |
Common papulosquamous lesions (raised/have scale) | Psoriasis; Seborrheic dermatitis; Pityriasis rosea; Lichen planus; Tinea corporis; Syphilis; Drug reaction |
Seb dermatitis: adults | infreq shampooing; bedridden / chronic ill; PD; persistent cases, check for fungal infxn |
Causes of lichen planus | Drugs (gold, chloroquine, methyl-dopa, penicillamine); film processing; Bac infxn (secondary syphilis); Post-BMT GVHD |
Wickham’s stria | lacy-reticulated pattern of white lines on surface; focal areas of epidermal thickening; in lichen planus |
Lichen planus sites | Most commonly on flexor surface of wrists and forearms; legs above the ankles; lumbar; eyelids; shins, scalp |
ACD acute vs chronic | Acute: macules, papules, vesicles, bullae; Chronic: lichenified, scaling, fissured lesions |
Darier sx | rubbing lesion causes urticarial flare |
Auspitz sx | pinpoint bleeding after scale is removed |
Nikolsky sx | pushing blister => further separation from dermis |
Shagreen skin: | oval nevoid plaque; skin pigmented on trunk/back; assoc w/tuberous sclerosis |
atopic dermatitis: itch-scratch cycle => pruritic circumscribed plaques = | lichen simplex chronicus |
5 P's of Lichen planus: | purple, polygonal, pruritic, papule, planar |
erythematous, annular patch w/central clearing; fine scale: | dermatophytosis |
varicella zoster is reactivation of VZV that was dormant in: | ganglionic satellite cells |
Hutchinson sign | VZV; involve trigeminal nerve => eye & nose |
Ramsay Hunt | VZV; affect external ear, facial palsy, & geniculate |
Beefy red, sharp bordered rash (patches/plaques) in groin (infants), under breast folds with satellite lesions | Candida |
Warm, erythematous, tender skin with possible induration or fluctuance | Cellulitis |
Red, less distinct borders; coral red fluorescence under Wood’s lamp: | Erythrasma (Corynebacterium minutissimum) |
Distinct, sharp raised demarcated border with fever, chills. Group A Strep | Erysipelas |
Grouped vesicles on erythematous base | Herpes virus |
Infant or pediatric w/ grouped vesicles on thumb or “tapioca” vesicles on thumb | Herpetic whitlow |
Pain preceding vesicular rash in dermatomal pattern | Herpes Zoster (if involved eye = herpes keratitis) |
if a group of lesions has a dermatomal distribution what disease is it likely to be | herpes zoster (shingles) |
Honey colored crusts on erythematous base around nose & mouth | Impetigo; tx: mupirocin |
Small white papules on diffusely red base on buccal mucosa = | Koplik spots: Rubeola (Measles); spots occur before rash |
Cough, coryza, conjunctivitis | Rubeola (Measles) |
Pastia’s lines, positive ASO titer | Scarlet fever (Grp A Strep) |
Strawberry tongue | Scarlet fever (Grp A Strep) |
Dewdrops on rose petal, pustules & vesicles in crops (different stages of healing), centripetal pattern = | Varicella (Chicken Pox) |
Christmas tree pattern, erythematous papules w/ oval plaques w/ scaly itchy border. Large oval plaque w/ central clearing & scaly border (herald patch) precedes rash by 1-2 weeks = | Pityriasis rosea (resolves in 6-12 weeks). May tx w/erythromycin stearate 250mg QID x2 weeks to prevent eruption |
Hypopigmented lesions, white, scaly. Gets worse w/ tanning or sun exposure | Pityriasis Alba |
Erythematic ring with scaly border & central clearing | Tinea (fungal infection); KOH prep = hyphae |
spaghetti & meatballs | Tinea (fungal infection |
Thick, yellow, brittle nails | Onychomycosis. Tx = PO Terbinafine |
Infant w/ erythematous, scaly crusty lesions at vertex of scalp | Cradle cap – seborrheic dermatitis (Tx in infants w/ baby shampoo, warm olive oil compress, mild Hydrocortisone cream; Adults – selenium sulfide shampoo) |
Children < 10yo w/ vesicles on pharynx, mouth, hands, feet w/ NO ulceration | Hand-Foot-Mouth disease. Coxksackie Virus |
Healthy looking < 5yo with lace-like rash on both cheeks – red papules | Erythema infectiosum; “Slapped cheek”, “5th Dz” (parvo B19) |
Pediatric with high fever then after fever macular rash over trunk and neck. (rash after defervesence) | Roseola infantum (Herpesvirus); Motrin, symptomatic treatment |
Truncal Rash in pediatric after fever | Roseola infantum (Herpesvirus); Motrin, symptomatic treatment |
Fever, pharyngitis, “sandpaper” rash over face, neck, trunk, extremities | Scarlet Fever |
High fever (up to 105F) x 5 days then rash. May have conjunctivitis, cracking, lip fissures | Kawasaki Disease; look for cardiac complications (myocarditis, pericarditis, arteritis, aneurysms) |
Erythema marginatum | Rheumatic Fever |
Dark skinned person with “whitening or lightening” of skin. Hx pernicious anemia or other autoimmune disease | Vitiligo. Skin biopsy to diagnose |
Postauricular & occipital LAD; maculopapular rash on face then spreads = | Rubella (german measles); dx w/paired sera; resolves in 4 days; sx tx |
Leser-Trelat sx: | Sudden eruption of many seborrheic keratoses may be a cutaneous sign of internal malignancy |
Dermatofibroma sites | usually legs, but also trunk & arms |
Dimple sign & button sign: for: | dermatofibroma |
junctional nevus: | clustered at the dermal-epidermal junction (DEJ); Flat or slightly raised, tan or brown, round or oval lesions |
compound nevus: | Nevus cells found at both the DEJ & in the dermis; Slightly to markedly raised, tan, brown, or black papules. |
intradermal nevus: | Raised, soft, flesh-colored, tan, or brown papules. Pigment may be arranged in flecks; may see coarse hairs |
halo nevus | rim of depigmentation; autoimmune; usually repigments; may be assoc w/vitiligo & malignant melanoma |
spitz nevus | kids (rarely adults); benign, pink, tan, or brown dome-shaped smooth papules; face, scalp, neck, and legs; rapid growth; excision bc melanoma may arise from spitz nevus |
developmental anomaly appearing as a brown patch, a patch of hair, or both: | Becker’s nevus |
Ephilides = | freckles |
Fordyce spots: | Ectopically located sebaceous glands |
These do not blanch well using diascopy: | cherry angioma |
Herpes keratitis tx | NO steroids. Get immediate ophthalmology referral |
oral candida (thrush) tx | fluconazole, itraconazole, or Ampho B |
Candidal fungemia tx | life threatening (40% mortality); IV ampho B; add flucytosine if disseminated dz |
hidradenitis suppurativa mgmt | If abscess: I&D then inject triamcinolone. Abx |
hidradenitis suppurativa risk factors | obesity, apocrine gland obstruction, FH of acne or hidradenitis suppurativa |
molluscum contagiosum etiology | Poxvirus (MCV-1 & MCV-2) via skin-skin contact. Mostly kids, adults (via sex) & pts with HIV |
Cellulitis in kids | H flu: tend to occur on face & neck. S aureus: tend to occur on extremities. GABHS also common organism |
Cellulitis organisms in adults | S aureus and GABHS |
Cellulitis tx | If penicillinase producer: Augmentin, dicloxacillin, azithro. If not: Pen VK, Keflex (esp for H flu) |
Necrotizing fasciitis tx | Oxacillin, nafcillin, or cefazolin IV |
Tx of sxs (eg, paronychia) in cutaneous candida | Castellani paint |
Cutaneous candidiasis tx | topical nystatin or imidazole cream QID x14d; if failure: Ketoconazole |
Most common benign tumors of infancy | Hemangiomas |
Hemangioma mgmt | Corticosteroids 1stline (Vincristine if resistant). Propranolol. Surgical: cryoablation |
Sudden enlargement of existing hemangioma with low platelets & coagulopathy = | Kasabach-Merritt syndrome (high mortality). Positive Glut-1 marker helps with dx |
Port wine stains (PWS) may be associated with: | Sturge-Weber syndrome (PWS in ophthalmic branch of trigeminal nerve) or Klippel-Trenauney-Weber syndrome (Parkes Weber syndrome if AVF) |