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BCPS study guide

anticoagulation

QuestionAnswer
clotting factors inhibited by warfarin II, VII, IX, X and protein C and S (anticoagulants)
half life of factor II 72 hours
half life of factor VII 6 hours
half life of factor IX 24 hours
half life of factor X 36 hours
in acute VTE, how long should you overlap warfarin and LMWH. why is this overlap necessary 5 days and INR 2+ for 24 hours. do this in order to fully suppress factor II. if not, will have suppressed protein C and S which act as anticoagulants but still have clotting from factor II which leads to a hypercoagulable state.
gene mutations associated with warfarin and what they alter VKORCI - alters warfarin sensitivity 2C9 - alters half life and metabolism
warfarin pregnancy category and breastfeeding preggers category X and ok with breastfeeding
Created by: mjuhlin
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