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Methylprednisolone
Question | Answer |
---|---|
GENERIC NAME | Methylprednisolone |
BRAND NAME | Solu-Medrol |
CLASS | Anti-inflammatory Glucocorticoid |
MECHANISM OF ACTION | Synthetic corticosteroid that suppresses acute and chronic inflammation; Potentiates vascular smooth muscle relaxation by beta-adrenergic agonist. |
INDICATIONS | Acute spinal cord trauma, anaphylaxis, bronchodilator for unresponsive asthma. |
CONTRAINDICATIONS | Premature infants, systemic fungal infections, Use with caution in patients with GI bleeding. |
ADVERSE REACTIONS | HA, HTN, Sodium and water retention, CHF, Hypokalemia, alkalosis, peptic ulcer disease, N/V |
NOTES ON ADMINISTRATION | Pregnancy safety not established, crosses the placenta and may cause fetal harm. Not effective if spinal cord injury is greater then 8 hours. |
INCOMPATABILITIES/DRUG INTERACTIONS | Hypoglycemic responses to insulin and hypoglycemic agents may be blunted. Potassium-depleting agents may exacerbate hypokalemic effects. |
DOSE/ROUTE Adult Acute spinal cord injury | 30mg/kg IV over 30 minutes followed by an infusion. |
DOSE/ROUTE Adult asthma and COPD | 1-2mg/kg IV. |
DOSE/ROUTE Pediatric | Same as adult |
ONSET OF ACTION | 1-2 hours |
PEAK EFFECTS | Variable |
DURATION OF ACTION | 8-24 hours |
AZ DRUG BOX SUPPLY RANGE | 250mg |