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P21-22 NSAID

Local Responses in Inflammation • Pain • Heat • Redness • Swelling • Loss of function
Anti-Inflammatory Drugs - therapeutic strategies •  Inflammation (anti-inflammation) •  Pain (analgesia) •  Fever (antipyrexia)
Acute Inflammatory Reaction • Innate immune response - rapid, release cytokines, direct: phagocytosis, anitimicrobial activity • Adaptive immune response - slow, recognition, gene rearrangement, response: T & B cells with receptors encoded by fully rearranged genes
Abnormal Immune Responses Extensive tissue damage (hypersensitivity), Reactivity against self antigens (autoimmunity), Impaired reactivity to appropriate targets (immunodeficiency)
Biological Effects of Eicosanoids - at site of inflammation • Dilate precapillary arterioles --> increse blood flow --> redness • Cause greater increase in permeability of postcapillary venules induced by histamine and bradykinin --> swelling • Potentiate pain production by bradykinin
classifications (x5) SPAOF 1. Salicylates 2. Proprionic acids 3. Acetic acids 4. Oxycams 5. Fenamates
Created by: hycocoma