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Anti Inflam Drugs
| Question | Answer |
|---|---|
| Salicylates Drugs | Aspirin (Bayer, Ecotrin).....baby:81mg, regular: 325mg given PO/PR/SR Mechanism: -Inhibit COX 1 and 2 enzymes Results in: -Anti inflammitory, Prostaglandins inhibition -Decreased platelet aggregation |
| Salicylates Drugs | Indicat: Chest Pains,Post cardiac event to reduce pain and inflammation, antipyretic Drug interaction: with (anticoagulant, anti platelets and NSAIDS) Adverse Reaction: -bleeding - allergy to aspirin(present with tennitis and broncospasms) |
| Salicylates Drugs | Precaution: -surgical stop 7-10 days prior -don't crush meds (enteric coated) -no ETOH -NOT FOR KIDS (cause rey's syndrome), Cat D |
| NSAIDS DRUGS | Ibuprofen (Motrin) and Advil PO Mechanism: Inhibits COX enzymes 1 & 2 Indication: antininflammatory, Antipyretics and Analgesics dosage: max 2400mg/day...highly protein bound Loss of stomach linning |
| NSAIDS DRUGS | Drug interaction: -Oral anticoagulant -increase effects of phenotoin(compete for same site) -Not for pregnancy -cause Nephrotoxicity -anaphylaxis -causes fluid retention |
| NSAIDS Contraindictions | -nsaids allergy -peptic ulcers -renal/hepatic failure -3rd trimester pregnancy -bleeding disorders -heart disease (exept ASA) -children -allergy to aspirin(present with tennitis and broncospasms) |
| NSAIDS N/I and P/T | - dosage adjustment for renal/hepatic pts -mon. s/s of bleeding -take with food -no othe anticoagulant unless px -no ETOH -off for 7-10 days b/4 surgery -avoid in trimester -deceses effectiveness of antihypertensives - for long term consider PPI |
| Herbal alert (may increase risk of bleeding with NSAIDS | -Garlic -Ginger -Ginko |
| Celecoxib (Celebrex)-PO | selective COX 2 INHIBITOR Indication: -Rheumatoid and osteoarthritis dosage: 200mg daily or divided**** Caution: renal/hepatic dysfunction heart failure hx of GI Bleeding anticoagulant use cardiac disease |
| Celecoxib (Celebrex)-PO Patient education | baby aspirin maybe px take with food no ETOH report gastric irritation cause fluid retention report s/s of heart attack S/E: gastric upset,diarrhea, heart burn, nausea ulcer, renal dysfunction give 2hrs before or after aluminum antacids |
| NSAIDS AND CELEBREX BLACK BOX WARNING | Cardiovascular risk may incr risk of serious and fatal cardiovascular thombotic events: MI and Stroke GI Risk may incr risk of serious and fatal GI adverse events:bleeding, ulcer and stomach or intestine perforations, elderly at most risk. |
| What is gout | its an inflammatory condition caused by increased uric acid.Gout, a painful form of arthritis, occurs when high levels of uric acid in the blood cause crystals to form and accumulate around a joint. -Its common in the big toe -purines increase acids |
| What is gout foods to avoid | purines in: - Meat -fish -alcohol -increase in fructose syrup normal levels 2.6-7.2 |
| ANTI GOUT DRUGS Allopurinols (Zyloprim) | -gout tx/prophylaxis -inhibits uric acid synthesis -take with food and fluid -can increase effect of warfarin(slow met. down warfar) -S/E: N/V, stomatitis,metallic taste Monitor CBC. Gout is assoc. with agranulation (critical decrease in WBC count) |
| ANTIGOUT Nursing Intervention | -Assess for renal/hepatic impairment (broken down through the liver) -dietary teaching -I/O's -assess serum uric acid levels -increase fluid intake - report S/E to HCP |
Created by:
amoniffa
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