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DU PA Scleroderma

Duke PA Scleroderma

Scleroderma is a Rheumatic disease characterized by __ fibrosis (thickening) of the skin (scleroderma) and internal organs (lungs, kidneys, heart, GI tract)
vascular dysfunction associated with scleroderma Raynaud’s phenomenon, digital ischemia, infarction
scleroderma is __ times more common in woment 3-4
onset of scleroderma is unlikely before decades __ 3-4
environmental factors implicated in scleroderma viral infection, silica
earliest manifestation of scleroderma Raynaud's phenomenon
results in endothelial injury→ increased permeability, abnormal smooth muscle cell proliferation and platelet aggregationbasement membrane thickens and fibrosis of the adventitial layers developsaffects capillaries, arterioles and even large vessels Raynaud's phenomenon
the tissue fibrosis in scleroderma is brought on by vasculopathy and autoimmunity
characterized by progressive replacement of normal tissue with dense connective tissue→ exuberant matrix remodeling and scar formation scleroderma fibrosis
__skin, lungs, tendon sheaths, heart, GI tract and some endocrine organsleads to functional impairment tissue fibrosis develops in
sclerodactyly thickened fingers
Created by: bwyche