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Pharm Ch 25
Drugs for Hypertension Key Terms
Term | Definition |
---|---|
aldosterone | hormone secreted by the adrenal cortex that increase sodium reabsorption in the distal tubule of the kidney |
angiotensin II | chemical released in response to falling blood pressure that causes vasoconstriction and release of aldosterone |
angiotensin-converting enzyme (ACE) | enzyme responsible for converting angiotensin I to angiotensin II |
antidiuretic hormone (ADH) | potent vasoconstrictor that can also increase blood pressure by raising blood volume |
baroreceptors | nerves located in the walls of the atria, aortic arch, vena cava, and carotid sinus that sense changes in blood pressure |
calcium channel blockers (CCBs) | drug that blocks the flow of calcium ions into myocardial cells |
cardiac output | the volume of blood pumped per minute |
chemoreceptors | nerves located in the aortic arch and carotid sinus that sense changes in oxygen content, pH, or carbon dioxide levels in the blood |
diuretics | substance that increases urine output |
hypertension (HTN) | the consistent elevation of systemic arterial blood pressure |
peripheral resistance | amount of friction encountered by blood as it travels through the vessels |
primary hypertension | HTN having no identifiable cause |
reflex tachycardia | temporary increase in heart rate that occurs when blood pressure falls |
renin-angiotensin-aldosterone system (RAAS) | body mechanism for raising blood pressure initiated by the release of renin by the kidney |
secondary hypertension | HTN that has a specific cause |
stroke volume | amount of blood pumped out by a ventricle in a single beat |
vasomotor center | area of the medulla that controls baseline blood pressure |
alpha 2 agonists | decrease sympathetic impulses from the CNS to the heart and arterioles, causing vasodilation |
alpha1 blockers | inhibit sympathetic activation in arterioles, causing vasodilation |
direct vasodilators | act on the smooth muscle of arterioles, causing vasodilation |
beta blockers | decrease the heart rate and myocardial contractility, reducing cardiac output |
calcium channel blockers | block calcium ion channels in arterial smooth muscle, causing vasodilation |
angiotensin receptor blockers | prevent angiotensin II from reaching its receptors, causing vasodilation |
diuretics | increase urine output and decrease fluid volume |
ACE inhibitors | block formation of angiotensin II, causing vasodilation, and block aldosterone secretion, decreasing fluid volume |