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handbook chapter 2
TQs
Question | Answer |
---|---|
Product of choice for treating hemophilia A | recombinant factor VIII |
Recombinant Factor VIII is produced in these cell lines | established hamster cell lines |
What disease do these products treat?: 1. Humate-P and 2. Alphanate | These products are intended for treatment of von Willebrand's disease |
What procedures are used to inactivate viruses in Factor VIII products? | nanofiltration, pasteurization and solvent/detergent treatment, and affinity chromatography preparation |
What infectious agents may escape pathogen inactivation processes in Factor VIII products? | non-lipid enveloped viruses like hepatitis A and parvovirus B19 |
Recombinant Factor IX is produced in these cell lines | Chinese hamster ovary cell lines |
Product of choice for treating hemophilia B | Recombinant Factor IX |
Indicated for the urgent reversal of warfarin | 4-factor concentrate (2,7,9,10), Kcentra (vitamin K dependent factors) |
This product treats ATIII deficiency | Anti-thrombin III concentrate |
Product of choice for treating or preventing bleeding episodes in patients with inhibitors to Factor VIII or IX | Recombinant factor VII (NovoSeven) |
Product of choice for treating or preventing bleeding episodes in patients with Glanzmann thrombasthenia | Recombinant factor VII (NovoSeven) |
These products can be used in Factor XIII deficiency when factor concentrate is not available. | FFP and cryoprecipitate |
How is albumin manufactured? | Cold alcohol fractionation |
Method to prevent viral disease transmission in albumin manufacturing process | heated to 60 degrees C for 10 hours |
% of albumin in a bag of albumin | 96% |
Composition of "plasma protein fraction" product: __% albumin; __% globulin | 83% and 17% |
The most common colloid used for volume expansion | HES, hydoxyethyl starch |
Immune globulins are prepared by cold ethanol fractionation from pools of human plasma from this many donors | 15,000 to 60,000 |
A miscarriage after this Estimated gestational age would require a 300microgram dose of Rhogam | 12 weeks EGA |
Dose of Rhogam is miscarriage occurs before 12 weeks | 50 microgram |
A full dose of Rhogam protects against alloimmunization to the D antigen after exposure up to __ mL of D-positive RBCs | 15mL |