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Pharmacology
Theory nitrates
Question | Answer |
---|---|
All nitrates are known collectively as | Nitrovasodilators |
All nitrates lead to the formation of what chemical? | Nitric oxide |
Pharmacological what effect do nitrates have on the body | Venous and arterial dilation: Dilation of veins predominates over that of arteriolar. As a result, a decrease in left and right ventricular EDP(preload) and a smaller decrease in systemic arterial pressure(after load). |
Venous and arterial dilation causes what in the heart | Decreasing myocardial workload and oxygen demand |
The realize of NO can cause e activation of what chemical | Cyclic GMP (cGMP) |
cGMP causes vasodilation by | Decreasing calcium levels in the cell |
What are are anti-anginals used for | Treatment and prevention if angina pectoris |
What are some side effects of nitroglycerin | Hypotension, headache,dizziness,tachycardia,flushing |
How is sublingual nitroglycerin administered | 1 tablet every 5 mins until, pain subsides or significant drop in BP. No more than 4-5 tabs if still in pain call i911 |
What is nitric oxide and what is it do | Free radical, inducescoronary vasodilation |
How do nitrates cause a reduction in venous return (preload) | increasing the venous capacitance causing pooling of blood in peripheral veins in there there by a reduction in venous return and ventricular volume |
True or false nitrates are better arterial then Venus dilators | False |
What is the gold standard of acute angina | Sublingual nitroglycerin |
To decrease the notorious nitrate tolerance, an"on/off strategy of at least ____ -______ nitrate-free interval" is practiced | 10-hour |
Intra-coronary NTG is used to minimize ischemia I do to coronary spasm true or false | True |
How does NTG relieve angina | It increases oxygen supply to the heart muscle |
The body relaxes vascular smooth muscle in that in arterial walls by releasing its own supply of | Nitric oxide |
Nitro paste is administered in what units of measure | Inches |
IV NTG is stored in class rather than plastic because | NTG is in activated by polyvinylchloride plastic |
Nitroglycerin would be contraindicated in | Severe hypotension |
Nitrates cause vasodilation by | Relaxing vascular smooth muscle |
Overdosage of sodium nitroprusside can result in cyanide poisoning the reversal agent for this Toxicity | Methylene blue |
The mechanism of nitroglycerin's effect on vascular smooth muscle is | Preventing calcium from initiating actin and myosin and coupling |
Reducing preload and afterload a reduces angina on by | Decreasing myocardial oxygen demand |
The usual sub lingual does a nitroglycerin | 0.4 mg |
nitroglycerin sublingual tablets should not be chewed because of reduction in potency caused by | First pass metabolism |